In the title compound, [Co(C(6)H(5)N(2)O(4))(2)(H(2)O)(2)]·2C(3)H(7)NO, the Co(II) ion lies on an inversion center and adopts a slightly distorted CoN(2)O(4) octa-hedral geometry binding two bidentate chelating 5-carb-oxy-2-methyl-1H-imidazole-4-carboxyl-ate (H(2)MIDA(-)) monoanionic ligands and two axial aqua ligands. In the crystal structure, inter-molecular O-H⋯O hydrogen bonds link neighbor...

The preparation of a number of agarose and polyacrylamide bead derivatives useful in the purification of proteins by afhnity chromatography is described. These techniques permit (a) the attachment of ligands to the gel through extended hydrocarbon chains which place the ligand at varying distances from the gel matrix backbone; (b) the covalent attachment of ligands to agarose or polyacrylamide ...

The preparation of a number of agarose and polyacrylamide bead derivatives useful in the purification of proteins by afhnity chromatography is described. These techniques permit (a) the attachment of ligands to the gel through extended hydrocarbon chains which place the ligand at varying distances from the gel matrix backbone; (b) the covalent attachment of ligands to agarose or polyacrylamide ...

The preparation of a number of agarose and polyacrylamide bead derivatives useful in the purification of proteins by afhnity chromatography is described. These techniques permit (a) the attachment of ligands to the gel through extended hydrocarbon chains which place the ligand at varying distances from the gel matrix backbone; (b) the covalent attachment of ligands to agarose or polyacrylamide ...

Imidazole molecules were frequently incorporated into porous materials to improve their proton conductivity. To investigate how different arrangements of imidazoles in metal-organic frameworks (MOFs) affect the overall proton conduction, we designed and prepared a MOF-based model system. It includes an Fe-MOF as the blank, an imidazole@Fe-MOF (Im@Fe-MOF) with physically adsorbed imidazole, and ...

This study presents both tumor-targeting ligands (cRGD) and pH-activated surface charge-conversional moiety (imidazole) decorated micelles for Dox delivery. cRGD is expected to induce preferential tumor accumulation, while imidazole switches on positive charge in a tumor acid environment, which leads to enhanced micelle uptake by tumor cells.

In the title three-dimensional compound, [CoSm(6)(C(5)H(2)N(2)O(4))(4)(SO(4))(6)(H(2)O)(14)](n), the Co(II) ion is six-coordinated with two O atoms and two N atoms from two imidazole-4,5-dicarboxyl-ate ligands and two coordinated water mol-ecules, giving a slightly distorted octa-hedral geometry. One Sm(III) ion is eight-coordinated in a bicapped trigonal-prismatic coordination geometry by four...

Kinetic and equilibrium data for the binding of azide, imidazole, and pyridine to horse heart ferricytochrome c have been obtained by conventional spectrophotometric and stopped flow techniques. The stability constants of the 1: 1 complexes formed between ferricytochrome c and the ligands are: azide, 4.5 M-‘; imidazole, 15.3 M-l; and pyridine, 2.4 M-l, at 25”, pH 7, and 1.0 M ionic strength. Th...

In weakly coordinating solvents FeII meso-(N-methylimidazol-2-yl)porphine Fe exists as a stable dimer (Kd=50+/-30 nM) that binds ligands without undergoing dissociation and is presently the simplest complex in which the mono-imidazole ligation of a ferroheme is enforced without excess imidazole in solution.

A general inability to carry out extensive variations in the electronic characteristics of proximal heme iron ligands in heme proteins has hampered efforts to obtain a clear understanding of the role of the proximal heme iron ligand in the activation of oxygen and peroxide. The disadvantage of the frequently applied site directed mutagenesis technique is that it is limited by the range of natur...