Two highly interesting papers related to osteoclastic activation in multiple myeloma were published in the December 15 issue of Blood.1,2 These studies were related to the imbalance of 2 molecules involved in the regulation of bone resorption: receptor activator of NF-kappaB ligand (RANKL) and osteoprotegerin. Croucher and colleagues2 found that mouse myeloma cells expressed RANKL mRNA and that...

BACKGROUND: Biosilica derived from Indonesian marine sponge Melophlus sarasinorum and Xestospongia testudinaria is one of the biomaterials that can be developed together with synthetic polymer as a composite. Poly E-caprolactone (PCL) used composite role an osteoconductive material biosilica also tailored slow rate degradation in body. This study aimed to create biocompatible biosilica-based sc...