The important role of genetic factors in the pathogenesis of narcolepsy was realized very early in the course of research on this disease. One of the first recognized instances of narcolepsy, reported by Westphal in 1877 (1), was a familial case, as the mother of his patient suffered from the same disease. More than 100 years later, in 1984, the groups of Juji and Honda in Tokyo (2), and of Lan...

There is overwhelming evidence for a major contribution of genetic elements to the aetiology of schizophrenia (Slater & Cowie, 1971), but the principal problems remain; what is the nature of the hereditary contribution, and what is the path by which genetic information is translated into a frank behavioural disorder? The genetic evidence comes not only from the well-known family studies (0degaa...

Hashimoto's thyroiditis (HT) is an organ-specific T-cell mediated disease. It is a complex disease, with a strong genetic component. To date, significant progress has been made towards the identification and functional characterization of HT susceptibility genes. In this review, we will summarize the recent advances in our understanding of the genetic input to the pathogenesis of HT.

SETTING: Two sample panels: (i) twenty pulmonary tuberculosis (TBp) patients and ten healthy subjects (HS) from a country with low incidence of TB (Italy) and (ii) forty-seven TBp patients and 26 HS from a country with high incidence of TB (Morocco). OBJECTIVE: To identify a combination of Mycobacterium tuberculosis (Mtb) peptides useful for the serodiagnosis of active TBp. METHODS: Fifty-seven...

the last two decades have seen a massive growth in the application of dna technology in histocompatibility and immunogenetics. this review summarises the history and application of dna methods in this area.

IMGT, the international ImMunoGeneTics information system http://imgt.cines.fr, was created in 1989 by the Laboratoire d'ImmunoGénétique Moléculaire (LIGM) (Université Montpellier II and CNRS) at Montpellier, France. IMGT is a high quality integrated knowledge resource specialized in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) of human and other vertebrat...

Bartosz Bugaj1*, Katarzyna Bogunia-Kubik2 and Jerzy Świerkot1 Author Affiliations 1Department of Rheumatology Internal Medicine, Wroclaw Medical University, Poland 2Laboratory Clinical Immunogenetics Pharmacogenetics, Hirszfeld Institute Immunology Experimental Therapy, Polish Academy Sciences, Received: January 29, 2022 | Published: February 16, Corresponding author: Bugaj, Department Borowska...

IMGT®, the international ImMunoGeneTics information system® (CNRS and Montpellier University) is the global reference in immunogenetics and immunoinformatics. By its creation in 1989, IMGT® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT® is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major ...