Immunotherapy is a promising cancer treatment approach that relies on awakening the immune system to the presence of antigens associated with tumor cells. The success of this approach depends on the ability to reliably detect immunogenic cancer mutations, the vast majority of which are expected to be tumorspecific [6]. In this poster we present a bioinformatics pipeline for detecting immunogeni...

Cartilage matrix is a particularly promising acellular material for cartilage regeneration given the evidence supporting its chondroinductive character. The ‘raw materials’ of cartilage matrix can serve as building blocks and signals for enhanced tissue regeneration. These matrices can be created by chemical or physical methods: physical methods disrupt cellular membranes and nuclei but may not...

We report a mechanism to induce combined and long-lived CD4(+) and CD8(+) T cell immunity to several mouse tumors. Surprisingly, the initial source of antigen is a single low dose of tumor cells loaded with alpha-galactosylceramide (alpha-GalCer) glycolipid (tumor/Gal) but lacking co-stimulatory molecules. After tumor/Gal injection intravenously (i.v.), innate NKT and NK cells reject the tumor ...

Water is indispensable and one of the precious natural resource of this planet. Ground water is an important source of water supply throughout the world. Fluoride poisoning arises from drinking fluoride rich ground water. Our present experiment was designed to study the efficacy of NaF on the splenocytes and its role in immunogenic response. The albino rats were taken for the experiment and ran...