The therapeutic effects of mesenchymal stromal/stem cells (MSCs) are mainly based on three characteristics: immunomodulation, tissue regeneration, and hematopoietic support. Cell therapy using culture-expanded MSCs is effective in some intractable bone and hemato-immune disorders; however, its efficacy is limited. In this article, we review the previous efforts to improve the clinical outcomes ...

The efficacy of mesenchymal stem cells regarding clinical outcomes and cartilage regeneration in knee osteoarthritis remains unclear; however, their theoretical role multilineage cellular differentiation immunomodulation the arthritic cascade has been investigated. Several studies have reported that use cell therapy for helps pain improvement, but its effect on not yet explored. Moreover, numer...

Abstract Glioblastoma (GBM) is an aggressive malignant adult brain tumor and characterized by poor prognosis survival outcome. Insufficient drug accumulation to the site development of monotherapy resistance are critical challenges overcome in combating GBM. Human induced neural stem cells (hiNSC) therapy promising due cells’ innate capability migrate tumors deliver therapeutics. We previously ...