Using two new immunoradiometric assays for thyrotropin, we measured thyrotropin levels in serum of patients suffering from various clinically and biochemically diagnosed thyroid disorders, and in healthy controls. A thyroliberin Stimulation test was performed in all patients and controls. Thyrotropin levels were measured using a solid phase IRMA in 339 patients and a coated tube sandwich assay ...

2010 platform (Roche Diagnostics). Ionized calcium and 25-hydroxyvita-min D (Nichols Advantage) were also measured in all samples. Results for the healthy individuals are presented in Fig. 1. The bio-intact PTH values measured by the IRMA and chemiluminescence immunoas-say were, on average, 50% and 30% lower, respectively, than the PTH measured by the Elecsys. Regression analysis demonstrated s...

Parathyroid hormone-related peptide (PTHrP) is recognized as the major causative agent of humoral hypercalcemia of malignancy (HHM). The paraneoplastic PTHrP has also been implicated in tumor progression and metastasis of many human cancers. Conventional PTHrP detection methods like immunoradiometric assay (IRMA) lack the sensitivity required to measure target peptide levels prior to the develo...

AIMS To study the effect of in-utero alcohol exposure on the insulin-like growth factor axis (IGF) and leptin during infancy and childhood, considering that exposed children may exhibit pre- and postnatal growth retardation. METHODS We prospectively identified heavily drinking pregnant women who consumed on average 4 or more drinks of ethanol per day (≥ 48 g/day) and assessed growth in 69 of ...

This investigation examined the hypothesis that acute heavy resistance exercise (AHRE) would increase overnight concentrations of circulating human growth hormone (hGH). Ten men (22 +/- 1 yr, 177 +/- 2 cm, 79 +/- 3 kg, 11 +/- 1% body fat) underwent two overnight blood draws sampled every 10 min from 1700 to 0600: a control and an AHRE condition. The AHRE was conducted from 1500 to 1700 and was ...

background: since the introduction of the first radioimmunoassay, several improvements have been made in the design of immunoassays such as method of antibody production, labeling, automation and detection technology. we performed an analytical evaluation of the new electrochemiluminescent immunoassay (eclia) for serum tsh, ft4 and t3 in the elecsys 2010 immunoassay system and compared the resu...

  Introduction: Prostate specific antigen (PSA) is one of the most sensitive markers for diagnosis of prostate cancer. Immunoradiometric kit (IRMA) is a common and sensitive method for determination of PSA in clinical laboratories. This kit has four major components: solid phase coated with monocolonal antibody, pair antibody labelled with I-125, series of standards i...

In this paper, we establish exact rate of strong uniform consistency for the local linear estimator of the conditional distribution function. As a consequence of our main result, we give asymptotic uniform certainty bands. We illustrate our results with simulations. 1Équipe Probabilités et Statistiques, IECN, Nancy-Université, CNRS, INRIA Bd des Aiguillettes, B.P. 239, 54506 Vandoeuvre-lès-Nanc...