Background Synthetic and biologic disease-modifying drugs (DMARDs) have improved the prognosis of systemic autoimmune diseases (SAD). However, concerns persist about infectious complications in these patients. Previous studies our group shownthat sublingual polybacterial vaccines decrease rateo recurrent respiratory tract infections (RRTI) urinary (RUTI). Objectives We aimed to evaluate number ...

Objective: One important, though poorly described, manifestation of Extra-pulmonary tuberculosis (EPTB) is that splenic (TB). We aimed to identify the epidemiological, clinical and radiological characteristics TB in Southern Tunisia analyse its therapeutic evolutionary modalities. Materials methods: TB-patients (pulmonary and/or extra-pulmonary) with abnormal parenchymal lesion on radiologial e...

INTRODUCTION Significant malnutrition exists in a high percentage of patients with head and neck cancer. Malnutrition is associated with defects in immune function that may impair the host response to malignancy. Malnutrition and immunosupression make patients highly susceptible to postoperative infections and complications. OBJECTIVES Some studies of patients receiving immuno-nutrition in th...

Glucocorticoids mediate a variety of biological effects via binding their intracellular receptor. Ligand-bound glucocorticoid receptor (GR) translocates to the nucleus and regulates gene transcription in a DNA binding-dependent or independent manner. The predominant biological effect of glucocorticoids on peripheral T cells is immunosupression via transcriptional repression of genes induced dur...

BACKGROUND Vancomycin-resistant enterococci colonization has been reported to increase the risk of developing infections, including bloodstream infections. AIM In this study, we aimed to share our experience with the vancomycin-resistant enterococci bloodstream infections following gastrointestinal vancomycin-resistant enterococci colonization in pediatric population during a period of 18 mon...

Average blood loss after total knee arthroplasty (TKA) usually ranges from 1500 to 1900 cc, including both the postoperative drain and hidden blood loss. This represents about 46% of TKA patients requiring postoperative blood transfusion. Not only the risks of disease transmission but also those of ABO incompatibility, infection due to immunosupression, increased procedure costs, and increased ...

We have read with interest the case report of severe gastrointestinal histoplasmosis in a patient infected with Human T lymphotropic virus-1 (HTLV1) by Canelo Aybar and colleagues [1]. In this case report, a possible link between these entities is suggested, but no conclusive evidence of a true association is provided. HTLV-1 causes clinical manifestations by three main mechanisms: autoimmune p...