BACKGROUND A negative electrophysiology study (EPS) may delineate a subgroup of patients with severely impaired left ventricular ejection fraction (LVEF) whose care can be safely managed long-term without an implantable cardioverter-defibrillator. METHODS AND RESULTS Consecutive patients treated with primary percutaneous coronary intervention for ST-segment-elevation myocardial infarction und...

BACKGROUND Implantable cardioverter-defibrillator therapy improves survival in patients with reduced left ventricular ejection fraction (LVEF) after acute myocardial infarction (AMI). Although the risk of sudden cardiac death is highest in the first month after AMI, there is no survival benefit of early implantable cardioverter-defibrillator implantation, and the optimal time frame has yet to b...

INTRODUCTION AND OBJECTIVES To summarize the findings of the Spanish Implantable Cardioverter-Defibrillator Registry for 2011 compiled by the Electrophysiology and Arrhythmia Section of the Spanish Society of Cardiology. METHODS Each implantation team voluntarily and prospectively recorded data on a data collection form, which was then sent to the Spanish Society of Cardiology. RESULTS Over...

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Background—T-wave alternans (TWA) increases before ventricular tachycardia (VT) or fibrillation (VF), suggesting that it may warn of VT/VF in implantable cardioverter-defibrillator patients. Recently, we described a method for measuring alternans and nonalternans variability (TWA/V) from electrograms (EGMs) stored in implantable cardioverterdefibrillators before VT/VF. The goal of this prospect...

Among 58 consecutive patients who underwent electrophysiologic testing for risk assessment and who subsequently received a third-generation implantable cardioverter-defibrillator, 39 had ventricular tachycardia induced in the baseline state and 19 had ventricular tachycardia induced only after administration of intravenous procainamide, increasing the yield of electrophysiologic risk assessment...

Sarcoidosis is a granulomatous disease of unknown pathogenesis that can affect virtually any organ system. Cardiac involvement results in significant morbidity and mortality, with some studies reporting that cardiac involvement accounts for up to 25% of all deaths from sarcoidosis in the United States and more than half of all deaths in Japan. Many deaths seem to be arrhythmic in nature and are...