The inclusion complex is one way to enhance active substance solubility, affecting medicine dissolution and penetration. formed by utilizing b-cyclodextrin as the host of compounds. Ibuprofen (2-(4-isobutyl-phenyl)propionate) a propionate acid derivative classified in class II Biopharmaceutic Classification System, which has low dissolutions high permeability. This study aims develop nanogel co...

Oxazolidine derivatives (OxD) have been described as third-line antibiotics and antitumoral agents. The inclusion complexes based on cyclodextrin could improve the solubility bioavailability of these compounds. A novel synthetic OxD was used, its were 2-hydroxy-beta-cyclodextrin (2-HPβCD). We conducted an in silico study to evaluate interaction capacity between 2-HPβCD. Characterization studies...

Paracetamol is a sparingly soluble bitter tasting drug. It is widely used as an analgesic and antipyretic. Complexation of drug with different cyclodextrins (?, ? and HP-?-CD) was attempted to improve solubility of Paracetamol. During the drug excipient interaction studies, ?, ? cyclodextrins elicited analytical interference and showed considerable absorbance at ?max (243.5 nm) of Paracetamol w...

The description logic (DL) SROIQ [1] provides a logical foundation for the new version of the web ontology language OWL 2. In comparison to the DL SHOIN which underpins the first version of OWL, SROIQ provides several new constructors for classes and axioms. One of the new powerful features of SROIQ are so-called complex role inclusion axioms (RIAs) which allow for expressing implications betwe...

The title inclusion complex, C(36)H(36)N(24)O(12)·C(8)H(14)N(2) (2+)·2I(-)·10H(2)O, displays a large ellipsoidal deformation of the cucurbit[6]uril (CB[6]) skeleton upon complex formation. The benzene ring of the cation is rotationally disordered between two orientations in a ratio of 3:1. The solvent H(2)O mol-ecules form a hydrogen-bonded network by inter-action with the carbonyl groups of CB...

The inclusion complexation of Epothilone A with native cyclodextrin (β- or γ-CD) and its derivative hydroxypropyl-β-cyclodextrin (HPβCD) were prepared. Their behavior, characterization, and binding ability were investigated in both solution and the solid state by means of UV-vis, NMR, XRD, DSC and SEM. The results show that the water solubility and solution stability obviously increased in the ...

beta-cyclodextrin can react with nitrobenzene to form an inclusion complex which is characterized by (1)H NMR and powder X-ray diffractometry. The ratio of beta-CD to NB in inclusion complex is determined as 1:1. At 25 degrees C, the dissociated constant, K(D), of the inclusion complex is measured as 6.5 x 10(-3) M in neutral solution (pH=7.0), but in alkali (pH=13.5), K(D) is 3.2 x 10(-2) M wh...

CSABA PAL RACZ1, ROXANA-DIANA PASCA1, SANTA SZABOLCS1, IRINA KACSO2, GHEORGHE TOMOAIA3, AURORA MOCANU1, OSSI HOROVITZ1, MARIA TOMOAIA-COTISEL1* 1Babes-Bolyai University of Cluj-Napoca, Faculty of Chemistry and Chemical Engineering, Department of Physical Chemistry, 11 Arany J. Str., 400028 Cluj-Napoca, Romania 2National Institute of Research and Development for Molecular and Isotopic Technologi...