I t is the object of this communication to give the results of experimental observations on the behavior of various animal cells toward certain substances belonging to the aromatic type, notably phenol and indol. ]:he inquiry was prompted by the interest wMch attaches to a Study of the natural defenses of the organism against various ]~inds of damage through chemical agencies. Prominent among t...

1. Indol is more hemolytic in the presence of a deficiency complex than when a normal diet is fed. 2. The hemolytic effect can be abolished by supplementing the deficient diet with liver extract curative of pernicious anemia in man. 3. The hemolysis affects all hemoglobin-containing cells, including reticulocytes. 4. The repair of the anemia resulting from the administration of indol in the pre...

A síntese dos ácidos 5,6-metilenodioxi-indol-3-il-metanóico 8 e 5,6-metilenodioxi-indol-3-ilacético 13 é descrita. Piperonal foi empregado como material de partida, sendo a construção do heterociclo altamente regioespecífica e está fundamentada na reação de Hemetsberger do correspondente β-azidoestireno. O composto 8 foi obtido como intermediário pivotal na preparação de 13, tendo-se conduzida ...

Os hormônios das plantas são de vital importância para o seu funcionamento normal. As auxinas são uma classe de fito-hormônios envolvidas em muitos aspectos do crescimento. Os ácidos indol3-acético (IAA), indol-3-pirúvico (IPA) e indol-3-lático (ILA) são auxinas com funções biológicas estimulantes do processo de crescimento, tais como elongação e divisão. Neste estudo, os valores pK a de IAA, I...

Indol-3-ylacetic acid stimulated stem elongation within 1 h of treatment of Pisum sativum L. cv. Feltham First stem sections. This elongation was accompanied by an increase in the endogenous level of phosphocholine and a decrease in that of CDP-choline. Measurements in vitro of the CDP-base pathway enzymes showed an increase in choline phosphotransferase and a decrease in cytidylyltransferase a...

The reaction of indole derivatives with cyanoacetic acid followed by treatment with DMFDMA gave the intermediate indolyl enaminonitriles (3). Further reaction with aminoguanidine yielded 5 ́-cyanomeridianin analogues (4). The same intermediate reacted with pmethoxyphenylhydrazine to give the pyrazolyl derivative (8). Treatment of (2E)-3-dimethylamino-2-(1H-indol-3-yl)-propenoate (3a) with hydrox...

The conceptually construction of axially chiral indolostilbenesi.eN-(2-{(E)-2-[2'-(1-Acetyl-1H-indol-2-yl)-3'chloro4,4',6,6'-tetramethoxy[1,1'-biphenyl]-2yl]ethenyl}phenyl)acetamide and N-(2-{(E)-2-[2'-(1-Acetyl-1H-indol-2-yl)-3'-chloro-2,4',6,6'tetramethoxy[1,1'-biphenyl]-4-yl]ethenyl}phenyl) acetamide are described in this paper. These structure, were obtained by the tactical combination of p...

In a search for novel nonsteroidal inhibitors of human prostatic 5alpha-reductase, we found a new series of indole derivatives that showed potent inhibitory activities for the human enzyme. Among them, 4-[(1-benzyl-1H-indol-5-yl)oxyl-3-chlorobenzoic acid (2d, YM-32906) showed more potent inhibitory activity than finasteride with an IC50 value of 0.44 nM. 3-Chloro-4-[[1-(4-phenoxybenzyl)-1H-indo...