PURPOSE Dravet syndrome (DS) is a rare disorder with seizure onset in the first year of life, typically beginning with prolonged febrile hemiclonic seizures or generalized tonic-clonic seizures. Photosensitivity is reported in more than 40% of patients. We present two cases of DS in which we had the chance to record occipital seizures induced by Intermittent Photic Stimulation (IPS). METHOD W...

objective(s): febrile seizures (fs) are the most common type of convulsive events among children. its prevalence has been estimated to be 2-5% in children between 3 months and 5 years old. also, blood and csf magnesium levels have been demonstrated to be reduced in children with fs. this study investigates the effect of mgso4 pretreatment on the behaviors caused by hyperthermia (ht) and effect ...

Background: Cicer arietinum (Chickpea) is one of the most important harvests in the world with high nutritional value. Lack of essential oils in the seeds of Chickpea is an advantage in search for drug-like molecules with less toxicity. We evaluated anticonvulsant effect of C. arietinum in common animal models of epilepsy. Methods: Dichloromethane extract was obtained from C. arietinum seeds by...

One of the major signs of severe organophosphate poisoning is seizures. Previous studies have shown that both muscarinic agonist- and organophosphate-induced seizures require activation of muscarinic acetylcholine receptors in the central nervous system. Seizures induced by the muscarinic agonist pilocarpine require the M1 receptor and are modulated by cannabinoid CB1 receptors. In this study, ...

Reflex seizures are seizures that are elicited by sensory or cognitive stimuli. These stimuli can be very diverse but are usually highly specific within one patient. The type of seizures that are induced by these stimuli can be tonic-clonic seizures, myoclonic jerks with or without absences, and absences with facial myoclonus. Focal seizures can also occur. A wide range of different stimuli hav...

Mice were administered anticholinesterase pesticides dichlorvos (DDVP) or methomyl (MET). Both DDVP and MET induced dose-dependent seizures and lethality in mice. The muscarinic antagonist atropine (ATR, 1.8 mg/kg) did not prevent seizures but diminished the lethality induced by DDVP or MET. The nicotinic antagonist mecamylamine (MEC, 1 mg/kg) affected neither DDVP-induced seizures nor DDVP- an...

objective(s):a growing interest has recently been attracted towards the identification of plant-based medications including those with protective effects against cognitive impairment. sesamol has shown promising antioxidant and neuroprotective effects, therefore, we aimed to evaluate its therapeutic potential in epilepsy which is commonly associated with oxidative stress and cognitive impairmen...

cognitive impairment in epileptics may be a consequence of the epileptogenic process as well as antiepileptic medication. thus, there is need for drugs, which can suppress epileptogenesis as well as prevent cognitive impairment. in the present study, the effect of khamira marwarid (kah 1 ), a formulation based on indian system of unani medicine, was evaluated on the course of pentylenetetrazole...