Lung cancer remains the leading cause of cancer death in American men and women. Non-small-cell lung cancer (NSCLC) accounts for 85% of these cases. Although surgery is the best curative approach for resectable NSCLC, long-term survival for patients with operable disease remains poor. More than half of patients who initially present with stage I to IIIA disease experience relapse of metastatic ...

There is interest in using leukemia-gene panels and next-generation sequencing to assess acute myelogenous leukemia (AML) response to induction chemotherapy. Studies have shown that patients with AML in morphologic remission may continue to have clonal hematopoiesis with populations closely related to the founding AML clone and that this confers an increased risk of relapse. However, it remains...

BACKGROUND AND PURPOSE Treatment of advanced stage squamous cell carcinoma of the upper aerodigestive tract with nonsurgical organ preservation protocols demonstrates improved cure rates with fewer comorbidities compared with surgery and radiation. The purpose of this study was to prospectively assess whether pretreatment evaluation of the primary site with quantitative CT perfusion measurement...

TO THE EDITOR—Pagano et al [1] analyzed the efficacy of antifungal prophylaxis with posaconazole and itraconazole in acute myeloid leukemia (AML) patients receiving induction chemotherapy. There were significant differences in the percentage of breakthrough proven/probable mold infections (posaconazole 2.7% vs itraconazole 10.7%; P = .02). The authors concluded that posaconazole prophylaxis con...

Background: Induction chemotherapy can produce dramatic necrosis in sarcomas—raising the question of whether or not radiation is necessary. This study reviews the clinical outcome of a subset of patients with high-grade extremity soft tissue sarcomas (STS) who were treated with induction chemotherapy and surgical resection but without radiation. Methods: Nonmetastatic, large, high-grade STS of ...

Gastric cancer with peritoneal dissemination may be diagnosed as unresectable. More recently, as a result of progress in chemotherapy, some patients with peritoneal dissemination have exhibited extended survival. We report on our experience with three patients in whom induction chemotherapy allowed for totally laparoscopic total gastrectomy (TLTG). All three patients were diagnosed as having ad...

Acute myeloid leukaemia Chemotherapy for AML is divided into two phases: induction and consolidation. The initial aim of induction treatment is to produce a “morphological complete remission” — ie, normal neutrophil and platelet counts and a reduction in the number of leukaemic blast cells to <5% of the total white blood cell count in the bone marrow. Induction regimens include cytarabine and a...

• The standard treatment depends on primary tumor location and extension. It could be surgery with or without postoperative radiotherapy or radiotherapy alone [I, A]. • Adjuvant chemotherapy has demonstrated no benefit [I, A]. Concomitant chemo-radiotherapy with single-agent platinum following surgery has shown a benefit for disease-free and overall survival in comparison with postoperative rad...

BACKGROUND Our previous individual patient data (IPD) meta-analysis showed that chemotherapy improved survival in patients curatively treated for non-metastatic head and neck squamous cell carcinoma (HNSCC), with a higher benefit with concomitant chemotherapy. However the heterogeneity of the results limited the conclusions and prompted us to confirm the results on a more complete database by a...

Prior to the past few years, development of new therapies for acute myeloid leukemia (AML) has been disappointingly slow. For several decades, standard therapy AML consisted intensive induction chemotherapy, and potentially a subsequent hematopoietic stem cell transplant. Unfortunately, older patients are less responsive to, frequently unfit tolerate, such chemotherapy. Given that majority elde...