PURPOSE Hypsarrhythmia, the pathognomonic EEG pattern of West syndrome, is typically characterized by a high amplitude, arrhythmic, and asynchronous pattern. While this severely aberrant pattern would suggest severe abnormalities in connectivity, coherence has not yet been systematically assessed in hypsarrhythmia. METHODS We evaluated the EEGs of 28 infants, 12 with infantile spasms with hyp...

BACKGROUND Management of infantile spasms is difficult because current treatment regimens, including many anticonvulsants and hormones, are often ineffective. We conducted this study to determine the effective dose of topiramate (TPM) in Taiwanese children with infantile spasms. METHODS Fourteen patients with infantile spasms were given TPM at an initial dose of 12.5 mg/d, and the dose was ra...

A 7-month-old boy with glutaric aciduria type 1 (GA1) presented with 1 week of clustered flexor spasms. Examination revealed mild axial hypotonia without encephalopathy. Video-EEG monitoring revealed hypsarrhythmia and infantile spasms (figure, A). MRI showed acute basal ganglia injury (figure, B). After 3 weeks of prednisolone treatment, 5-month follow-up showed continued resolution of hypsarr...

PURPOSE To investigate the informative value of EEG and cranial magnetic resonance imaging (cMRI) in the prognosis of infantile spasms (ISs); 86 patients with ISs were included in this study. METHODS All cases had epileptic spasms, psychomotor retardation, and hypsarrhythmia in at least one of their EEGs. cMRIs and laboratory tests necessary for etiologic diagnosis were completed in all cases...

BACKGROUND Adrenocorticotrophic hormone (ACTH) and prednisone are both used to treat infantile spasms (IS) in West syndrome. In many countries, ACTH is expensive and difficult to obtain whereas, prednisone or prednisolone are cheap, given orally and easily available. AIMS The purpose of this retrospective data analysis was to compare the efficacy and cost of ACTH and prednisolone in the treat...

We report the case of an 18-month-old child with infantile spasms and a hypsarrhythmic electroencephalogram (EEG) pattern associated with a porencephalic cyst. Surgical removal of the cyst and its surrounding tissue was performed following failure of medical therapy. Postoperatively, the patient has been free of infantile spasms for 12 months and the EEG has normalized. He has been maintained o...

To study the incidence of cerebral visual impairment among children with history perinatal neurological insult and congenital brain anomalies to analyze outcome following intervention programme. A prospective interventional study, examining 100 less than 7 years over a period 1 year. All hypoxia, neonatal hypoglycemia, seizures, infantile spasm, epilepsy, hydrocephalus, anomalies, CNS infection...

objective infantile spasms (is) or west syndrome is a convulsive disease characterized by brief, symmetric axial muscle contractions (neck, trunk, and/or extremities).the therapy universally recognized as most effective in the treatment of is, is treatment with the adrenocorticotropic hormone (acth) or oral corticosteroids. this therapy however has important side effects. many studies have soug...