Repetitive application of topical imiquimod is used as an experimental model for the induction of psoriasiform skin lesions in mice. The model is characterized by several inflammatory processes, including cytokine production both locally and systemically, cellular infiltration, and splenomegaly. To investigate the production of type I interferons in response to imiquimod-containing Aldara cream...

<i>Helicobacter pylori (H. pylori)</i>-negative gastric cancer is diagnosed when malignancies are found in patients <i>H. pylori</i>-naïve stomachs. There four types of noncardiac pylori</i>-negative cancers. The signet ring cell-type poorly cohesive carcinoma most common, followed by the chief cell-predominant type adenocarcinoma fundic gland. Extremely well-diffe...

We have investigated the role of antigen-processing machinery (APM) component defects in HLA class I antigen downregulation in laryngeal squamous cell carcinoma (SCC) lesions and assessed the clinical significance of these defects. To this end, 63 formalin-fixed, paraffin-embedded tumor lesions were examined for APM component and HLA class I antigen expression by immunohistochemistry. Calnexin,...

We have investigated the role of antigen-processing machinery (APM) component defects in HLA class I antigen down-regulation in laryngeal squamous cell carcinoma (SCC) lesions and assessed the clinical significance of these defects. To this end, 63 formalin-fixed, paraffin-embedded tumor lesions were examined for APM component and HLA class I antigen expression by immunohistochemistry. Calnexin...

We previously demonstrated that renal peptidyl arginine deiminase-4 (PAD4) is induced after renal ischemia and reperfusion (I/R) injury and exacerbates acute kidney injury (AKI) by increasing the renal tubular inflammatory response. Here, we tested whether genetic ablation of PAD4 attenuates renal injury and inflammation after I/R in mice. After renal I/R, PAD4 wild-type mice develop severe AKI...

Abstract Background : Cervical cancer is the fourth commonly occurred in women around world. However, it still lacks effective approaches to improve current prognosis of cervical and prevent metastasis. Objective We aim discover a promising biomarker for by utilizing bioinformatics analysis. Methods Gene expression was analyzed datasets from The Cancer Genome Atlas Program-Cervical squamous cel...

objective: this study investigated the effects of adipose-derived mesenchymal stem cells (mscs) and conditioned medium injection on cell infiltration in the brains of an experimental c57bl/6 mice model of autoimmune encephalomyelitis (eae). methods: eae was induced with myelin oligodendrocyte glycoprotein (35-55 peptides) in 20 mice. mscs were obtained from the adipose tissue of c57bl/6 mice a...

The aim of the study was to investigate the effects of sildenafil citrate (SC) on renal ischemia reperfusion (I/R) injury in a rat model. Forty eight male Wistar albino rats were randomly assigned into six groups: sham, ischemia, I/R, SC+sham, SC+ischemia and SC+I/R. In the I/R groups, the right kidney was removed and the artery and vein of the left kidney were clamped for 45 min followed by re...

Though it is vital to estimate infiltration as one of the key factors in effective management of water resources, only few studies have been carried out either to determine the infiltration or to compare the performance of infiltration models for coarse textured soils. Thus, the present study was conducted to accomplish two objectives. First to estimate the Horton’s infiltration model parameter...