In genetically susceptible individuals, an altered mucosal immune response against some commensal bacteria of the gut ecosystem appears to be the principal mechanism leading to intestinal lesions in inflammatory bowel disease (IBD). The information currently available does not provide an exact explanation about the origin of this important dysfunction of the interaction between host and commens...

Inflammatory bowel diseases are associated with various hepatobiliary disorders, reported both in Crohn's disease and ulcerative colitis. They may occur at any moment in the natural course of the disease. The prevalence of liver dysfunction rises from 3% to 50% accordingly to definitions used in different studies. Fatty liver is considered as the most common hepatobiliary complication in inflam...

Inflammatory bowel diseases (IBD) are chronic inflammatory disorders, including Crohns’ disease (CD) and ulcerative colitis (UC), both characterized by a clinical relapsing course an immune-mediated pathogenesis [...]

background there are great variations in the incidence and prevalence of inflammatory bowel diseases (ibd) among different populations. epidemiologic studies mainly come from north america and europe. studies from iran are mostly data on the adult population from the northern region of the country. methods medical records of 37 pediatric patients (≤ 18 years of age) admitted in the pediatric ga...

Valuable clinical indicators for identifying infantile-onset inflammatory bowel disease patients with monogenic diseases

background: musculoskeletal manifestations (msm) of inflammatory bowel diseases (ibds) are usually the most frequent extraintestinal manifestations. however, they are not paid enough attention during regular office visits. this cross-sectional study aimed to draw a clinical picture of msm and their relationships with other findings in patients with ibd. materials and methods: patients of our ib...