The air we breathe inside buildings dominates overall inhalation exposure to most air pollutants, whether of indoor or outdoor origin. The same is true for our exposure to microorganisms. Over the past three decades much has been learned about chemicals (in gas and particle phases) in building air, including typical levels, sources, fate, and control. Far less has been learned about the types, ...

Several epidemiologic studies have suggested an association between childhood asthma and exposure to disinfection by-products (DBPs) in the swimming pool environment. In August 2007 a group of clinicians, epidemiologists, exposure scientists, pool operations experts, and analytical chemists met to discuss the literature on childhood asthma and swimming pools, and to develop recommendations for ...

Several epidemiologic studies have suggested an association between childhood asthma and exposure to disinfection by-products (DBPs) in the swimming pool environment. In August 2007 a group of clinicians, epidemiologists, exposure scientists, pool operations experts, and analytical chemists met to discuss the literature on childhood asthma and swimming pools, and to develop recommendations for ...

In situations involving radiation exposure and acute inhalation exposure of chemicals, among others, actual exposure to a target organ is not available. Instead, interdisciplinary teams build complex, often differential equation–based models relating a measure of exposure to actual exposure at a target organ. These complex models are themselves filled with uncertainties, e.g., in transition rat...

Several epidemiologic studies have suggested an association between childhood asthma and exposure to disinfection by-products (DBPs) in the swimming pool environment. In August 2007 a group of clinicians, epidemiologists, exposure scientists, pool operations experts, and analytical chemists met to discuss the literature on childhood asthma and swimming pools, and to develop recommendations for ...

This paper provides an outline of the Advanced REACH Tool (ART) version 1.0 and a discussion of how it could be further developed. ART is a higher tier exposure assessment tool that combines mechanistically modelled inhalation exposure predictions with available exposure data using a Bayesian approach. ART assesses exposure for scenarios across different plants and sites. Estimates are provided...

There is considerable variability in the published lethality values for inhalation exposures of Bacillus anthracis. The lack of consensus on an acceptable dose-response relationship poses a significant challenge in the development of risk-based management approaches for use following a terrorist release of B. anthracis spores. This article reviewed available B. anthracis dose-response modeling ...

The effect of tail pinch on acetylcholine release in the striatum of freely moving rats was studied by microdialysis immediately after inhalation exposure to toluene (2000 ppm, 2 h) or exposure to air only. It has recently been found that toluene increases extracellular dopamine levels while decreasing acetylcholine release, and that dopamine uptake inhibition increases both extracellular dopam...

An inhalation exposure system, consisting of an inhalation chamber and an generating and feeding device for welding fumes and gases with a welding robot, was constructed and examined for its application to experimental toxicology for ventilatory responses of conscious rats to welding fumes and gases. The exposure system allowed an inhalation of fresh welding fumes and gases, and could supply ai...

The application of a proportional-integral-derivative (PID) control algorithm to an inhalation exposure system using a building automation system is described. Previous studies had utilized a control system in which concentration was monitored continuously and adjustments to the generator were made on a continuous basis. In this system, benzene vapor was generated into a chamber, and a gas chro...