Drug discovery proceeds as a multi-stage process, from the identification of a potential therapeutic target through lead generation, lead optimization, preclinical evaluation to clinical testing, before a new medicine is marketed. Uniting synthetically accessible chemical space with disease relevant biological space represents a significant challenge. Industrial chemical biology approaches have...

The process of tooth mineralization and the role of molecular control of cellular behavior during embryonic tooth development have attracted much attention the last few years. The knowledge gained from the research in these fields has improved the general understanding about the formation of dental tissues and the entire tooth and set the basis for teeth regeneration. Tissue engineering using s...

The respiratory system, as well as the skin, are organs in direct contact with the environment and they represent possible doors for the entrance of therapeutic agents into the body. Because of the increasing incidence of pulmonary diseases with high mortality and morbidity, pulmonary drug delivery is emerging as a non-invasive and attractive approach for the treatment of several pathologies. I...

Automatic name dialing is a practical and interesting application of speech recognition on telephony systems. The IBM name recognition system is a large vocabulary, speaker independent system currently in use for reaching IBM employees in the United States. In this paper, we present some innovative algorithms that improve name recognition accuracy. Unlike transcription tasks, such as the Switch...

According to the American Diabetes Association, the cost of treating diabetes in North Carolina was approximately $5.3 billion in 2006. Reigning in diabetes-related costs requires collaboration between third-party payers, health care professionals, and people with diabetes. This article reviews innovative policy changes that affect all 3 groups and are intended to improve diabetes-associated ca...

Urethral strictures are a common urologic disease that arises from varied etiologies. These strictures range in severity from simple, short lesions to complex, long defects. Likewise, the management approach varies based on the complexity of the lesion. We reviewed the literature of urethral stricture disease and its management. In particular we have focused on complex strictures of the male pe...

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