MicroRNAs (miRNAs) are a class of recently discovered non-coding small RNA molecules, on average approximately 21 nucleotides in length, which underlie numerous important biological roles in gene regulation in various organisms. The miRNA database (release 18) has 18,226 miRNAs, which have been deposited from different species. Although miRNAs have been identified and validated in many plant sp...

The influenza A virus affected a worldwide pandemic outbreak in 2009. Due to the reoccurrence of H1N1 pandemic there is a necessity to study the H1N1 proteins. Influenza A virus is a lipid-enveloped orthomyxovirus and a origin of human disease by strains that arise through periodic variation and through pandemic infection causing from viral adaptation that introduces new influenza viruses into ...

Patients suffering from the congenital Long-QT syndrome have been reported to react highly sensitive to the presence of β-adrenergic agents that are produced by the sympathetic nervous system. In this work we used an anisotropic and electrophysiologically heterogeneous insilico model to reproduce wedge experiments in which the Long-QT syndrome was induced pharmacologically. The integration of a...

Thromboembolic disease is caused by improper functioning of the blood coagulation process. The serine protease Factor Xa plays a central role in the coagulation cascade. FXa inhibitors have been identified to maintain a patient’s blood level within the therapeutic range and also shown to activate clotting over a much wider concentration range than thrombin in invitro assays. Predicting the bind...

The objective of this study was to characterize and validate the candidate point mutation in Calcium channel, voltagedependent, alpha-2/ delta subunit 1 (CACNA2D1) gene in Karan Fries (Bos taurus x Bos indicus) cattle. The CACNA2D1 gene reported as one of the potential candidate gene influencing Somatic cell Score and Mastitis. A PCR product of 249 bp amplifying the exon 19 and partial 18 and 1...