BACKGROUND AND PURPOSE Case reports have shown an association between right insular damage and neglect. The aim of this study was to examine the incidence of neglect among patient groups with right or left insular infarction. METHODS We examined neglect in 9 right-handed subjects with insular stroke as evidenced by CT and/or MRI scans (4 with right insular and 5 with left insular cerebrovascu...

UNLABELLED The processing of interoceptive signals in the insular cortex is thought to underlie self-awareness. However, the influence of interoception on visual awareness and the role of the insular cortex in this process remain unclear. Here, we show in a series of experiments that the relative timing of visual stimuli with respect to the heartbeat modulates visual awareness. We used two mask...

Drug-associated memories are critical for addictive behaviors, as these memories can trigger drug seeking and relapse by contextual cues. The transfer of lactate from astrocytes to neurons plays an important role in reward memory. Recently, studies have indicated that the insular cortex has a vital role in addictive procedure, which can be induced by contextual cues using both rat and human mem...

aim and background: it has since long been known that there is strong relation between   psychological status and functional gastrointestinal disorders (fgid). however, until recently, the nature of this putative relationship was unclear due to a lack of non-invasive methods to investigate the neurobiological mechanisms underlying this relationship.  functional brain imaging has provided a meth...

The insular cortex is circumscribed with three limiting sulci, so progression patterns of insulo-opercular gliomas can be categorized into tumor progression limited to the insular cortex, tumor progression via the anterior limiting sulcus, tumor progression via the inferior limiting sulcus, and tumor progression via the superior limiting sulcus. Recent improvements in clinical accessibility and...

The molecular and cellular mechanisms of memory storage have attracted a great deal of attention. By comparison, little is known about memory allocation, the process that determines which specific neurons in a neural network will store a given memory. Previous studies demonstrated that memory allocation is not random in the amygdala; these studies showed that amygdala neurons with higher levels...

For a long time, the insula has fascinated anatomists, physiologists, and surgeons because of its complex role and technically challenging access.3,13,35,38,50,53–55,67 Following the publication of Yaşargil et al., thanks to technical developments and a better understanding of insular functional anatomy, some experiences of insular surgery have recently been reported.13,20,33,50,53,55,64,67,69 ...

Long-term potentiation of glutamatergic transmission has been observed after physiological learning or pathological injuries in different brain regions, including the spinal cord, hippocampus, amygdala, and cortices. The insular cortex is a key cortical region that plays important roles in aversive learning and neuropathic pain. However, little is known about whether excitatory transmission in ...