نتایج جستجو برای: insulin potassium gik
تعداد نتایج: 258625 فیلتر نتایج به سال:
CONTEXT Laboratory studies suggest that in the setting of cardiac ischemia, immediate intravenous glucose-insulin-potassium (GIK) reduces ischemia-related arrhythmias and myocardial injury. Clinical trials have not consistently shown these benefits, possibly due to delayed administration. OBJECTIVE To test out-of hospital emergency medical service (EMS) administration of GIK in the first hour...
The “holy grail” in the field of cardioprotection is to develop pharmacological agents that can be administered as adjunctive treatment to reperfusion that will reduce myocardial infarct size and improve clinical outcomes. Numerous pharmacological agents and strategies have been studied over the years with variable results in both animal models and humans. Of drugs that have been studied, only ...
BackgroundCABG is one of the most common surgical procedures, especially among heart surgeries. Protection of the myocardium during and after the early stages of operation has special importance. Different medical and drug techniques have been used for this purpose. One of these techniques is infusion of glucose-insulin-potassium (GIK) solution. We compared the efficacy of GIK solution and GIKm...
BACKGROUND Glucose-insulin-potassium (GIK) therapy has been advocated for the treatment of acute myocardial infarction. However, the results from the clinical trials have been inconclusive, largely because of the small number of patients recruited and discrepancies between protocols used in these studies. METHOD AND RESULTS A systematic MEDLINE search for all the randomized placebo-controlled...
The negative results of glucose-insulin-potassium (GIK) in the very large CREATE-ECLA trial that studied 20,201 patients with ST-elevation acute myocardial infarction (AMI), are disappointing and warrant thorough evaluation. We attempt to put the new data into perspective and uncover the serious flaws in the trial design, otherwise the whole metabolic concept will be disparaged. The crucial iss...
AIMS Remote ischaemic conditioning (RIC) has been shown to reduce myocardial infarct size in patients. Our objective was to investigate whether the combination of RIC with either exenatide or glucose-insulin-potassium (GIK) is more effective than RIC alone. METHODS AND RESULTS Pigs were submitted to 40 min of coronary occlusion followed by reperfusion, and received (i) no treatment, (ii) one ...
We studied the influence of glucose (G), insulin (I) and potassium (K) on vulnerability to ventricular fibrillation (VF) of the nonischemic canine myocardium. Vulnerability was assessed by determining VF and repetitive extrasystole (RE) thresholds with a single stimulus applied to the right ventricular endocardium during the vulnerable period. Electrical testing of the heart was performed befor...
BACKGROUND The IMMEDIATE Trial of emergency medical service use of intravenous glucose-insulin-potassium (GIK) very early in acute coronary syndromes (ACS) showed benefit for the composite outcome of cardiac arrest or in-hospital mortality. OBJECTIVES This analysis of IMMEDIATE Trial data sought to develop a predictive model to help clinicians identify patients at highest risk for this outcom...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید