BACKGROUND There are few studies that investigated the correlation between insulin resistance (IR) and the coronary artery remodeling. The aim of the study is to investigate the association of IR measured by homeostasis model assessment of insulin resistance (HOMA-IR) and coronary artery remodeling evaluated by intravascular ultrasound (IVUS). METHODS A total of 298 consecutive patients who r...

Homeostasis model assessment of insulin resistance (HOMA-IR) is a simple and useful method for evaluating insulin sensitivity. But it is difficult to apply to type2 diabetes patients treated with insulin. We have devised a method for measuring HOMA-IR and investigated the validity of HOMA-IR for evaluating insulin sensitivity in patients with type 2 diabetes on insulin therapy. In the first arm...

Insulin resistance is closely associated with both aging and overweight; yet in old age, weight loss is common, although insulin resistance increases. To study this paradox, the authors evaluated the role of insulin resistance in weight change among older adults from the Rancho Bernardo Study cohort. Participants were 725 nondiabetic men and women who were aged 50-89 years when weight and insul...

background: non-alcoholic fatty liver disease (nafld) is characterized by fatty change of liver without inflammation. the aim of this study was to evaluate presence of clinical and metabolic components in non-diabetic patients with nafld and to assess the relationship between insulin resistance and these factors. materials andmethods: in this study, a group of 50 sonographically confirmed patie...

OBJECTIVE To evaluate the incidence of hypogonadism in men with metabolic syndrome and its correlation with serum insulin levels. METHODS Observational, transversal study with 80 men with metabolic syndrome. The individuals were divided into two groups: Group 1: 56 patients (70%) with total testosterone > 300 ng/dL (normal gonadal function); Group 2: 24 patients (30%) with total testosterone ...

Insulin resistance is closely associated with atherosclerosis and cardiovascular mortality in the general population. Patients with end-stage renal disease (ESRD) are known to have insulin resistance, advanced atherosclerosis, and a high cardiovascular mortality rate. We evaluated whether insulin resistance is a predictor of cardiovascular death in a cohort of ESRD. A prospective observational ...

objectives: to investigate fasting glucose, glucose tolerance, insulin resistance and insulin–like growth factor 1 in patients with or without colorectal polyps. materials and methods: in this cross-sectional study, we evaluated fasting glucose, insulin, insulin–like growth factor 1 (igf-1), lipid profile and glucose tolerance test in 103 patients undergoing colonoscopy (52 normal and 53 with a...

UNLABELLED Summay: BACKGROUND Insulin resistance is an important pathogenic factor in type 2 diabetes patents. An easy and efficiency measurement predicting insulin resistance; which can be done easily by type 2 patients is desired. OBJECTIVE To examine whether waist circumference is a better predictor of insulin resistance in type 2 diabetes than body mass index (BMI). METHODS From a pop...

BACKGROUND Whether insulin resistance predicts ischemic stroke (IS) is still a matter of debate. OBJECTIVE To determine the association between insulin resistance (IR) and risk of first ischemic stroke in a large, multiethnic, stroke-free cohort without diabetes. DESIGN Prospective, population-based cohort study. SETTING Longitudinal epidemiologic study. PARTICIPANTS A cohort of 1509 no...

AIM This study examined β-cell function and insulin resistance (homeostasis model assessment-insulin resistance [HOMA-IR]) in Asian Indian youth with type 2 diabetes mellitus (T2DM-Y) and prediabetes. SUBJECTS AND METHODS Eighty-two subjects with non-insulin-requiring type 2 diabetes and age of onset below 25 years were recruited within 18 months of diagnosis and compared with age- and sex-ma...