Many biological processes rely on targeted protein degradation, the dysregulation of which contributes to the pathogenesis of various diseases. Ubiquitin plays a well-established role in this process, in which the covalent attachment of polyubiquitin chains to protein substrates culminates in their degradation via the proteasome. The three-dimensional structural topology of ubiquitin is highly ...

In order to gain a full understanding of a biological process, we must be able to augment the known molecular interactions with discovered knowledge. We believe that a visualization system works as a means for accomplishing this task, as it provides an intuitive base for necessary information, among others. However, reported implementations have further problems: (1) The size of the information...

Business-to-business interaction (B2Bi) is the next step for corporate IT [1]. Business relationships become increasingly dynamic, and new requirements emerge for data and process management. Standardisation initiatives are successfully targeting business ontology [4]. Still, business agility mainly depends on the flexibility of the business processes of a company. In the B2B space, traditional...

We present an interaction protocol based approach for facilitating distributed construction processes. In our approach, software agents represent various participants of a construction project. Examples of such are contractor, subcontractor, and supplier. These agents are supposed to communicate according to predefined interaction protocols. Should an agent be unaware of some protocol needed in...

We consider a class of random point and germ-grain processes, obtained using a rather natural weighting procedure. Given a Poisson point process, on each point one places a grain, a (possibly random) compact convex set. Let be the union of all grains. One can now construct new processes whose density is derived from an exponential of a linear combination of quermass functionals of. If only the ...

This research is concerned with the processes by which individuals use social interaction to actively test hypotheses about other people. In four separate empirical investigations, female participants were provided with hypotheses about the personal attributes of other individuals ("targets"). Participants then prepared to test these hypotheses (i.e., that their targets were extraverts or that ...

The number of interactions among environmental factors and plant genetic constraints makes an assessment of plant responses to global change factors difficult to solve by experimentation alone. Mechanistically-based Functional-Structural Plant Models (FSPMs) however, have the potential to predict the effects of subtle interactions among environmental driving variables on key physiological proce...

Problem statement: Verification of correct functionality of semiconductor devices has been a challenging problem. Given the device fabrication cost, it is critical to verify the expected functionality using simulations of executable device models before a device manufactured. However, typical industrial scale devices today involve large number of interactions between their components. Complexit...

Massive stars end their lifes as type II supernovae, triggered by a collapse of their central iron core with a mass of more than 1M . The general picture of a core-collapse supernova is probably well understood and has been confirmed by various observations from supernova 1987A. Nevertheless, the most sophisticated supernova simulations [1, 2, 3] currently fail to explode indicating that improv...