نتایج جستجو برای: interleukin 1 receptor antagonist protein

تعداد نتایج: 3928682  

Journal: :The American journal of physiology 1999
Johan Lundkvist Anna K Sundgren-Andersson Susanne Tingsborg Pernilla Östlund Catherine Engfors Katarina Alheim Tamas Bartfai Kerstin Iverfeldt Marianne Schultzberg

The interleukin-1 (IL-1) receptor antagonist (IL-1ra) is an endogenous antagonist that blocks the effects of the proinflammatory cytokines IL-1α and IL-1β by occupying the type I IL-1 receptor. Here we describe transgenic mice with astrocyte-directed overexpression of the human secreted IL-1ra (hsIL-1ra) under the control of the murine glial fibrillary acidic protein (GFAP) promoter. Two GFAP-h...

2017
Catharina M. Mulders-Manders Marije C. Baas Femke M. Molenaar Anna Simon

In patients undergoing solid organ transplantation, the presence of an interleukin-1 (IL-1) driven disease may require the addition of IL-1 inhibiting drugs to the standard immunosuppressive regimen to protect against inflammation and negative graft outcome. Three patients undergoing renal transplantation were treated perioperatively with the interleukin-1 receptor antagonist anakinra. Kidney f...

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