interleukin 7 receptor

David A Hafler Alastair Compston Stephen Sawcer Eric S Lander Mark J Daly Philip L De Jager Paul I W de Bakker Stacey B Gabriel Daniel B Mirel Adrian J Ivinson Margaret A Pericak-Vance Simon G Gregory John D Rioux Jacob L McCauley Jonathan L Haines Lisa F Barcellos Bruce Cree Jorge R Oksenberg Stephen L Hauser

BACKGROUND Multiple sclerosis has a clinically significant heritable component. We conducted a genomewide association study to identify alleles associated with the risk of multiple sclerosis. METHODS We used DNA microarray technology to identify common DNA sequence variants in 931 family trios (consisting of an affected child and both parents) and tested them for association. For replication,...

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Prognostic value of the immune microenvironment in lung adenocarcinoma

2013

Kyuichi Kadota Jun-ichi Nitadori Prasad S. Adusumilli

We analyzed the immune microenvironment in the neoplastic and stromal components of Stage I lung adenocarcinoma lesions, finding that a high ratio of tumor-infiltrating FOXP3+ regulatory T cells to CD3+ lymphocytes, an elevated expression of the interleukin-7 receptor, as well as a reduced expression of the interleukin-12 receptor β2 all constitute independent factors of poor prognosis.

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