BACKGROUND & OBJECTIVE Cytokines play an important role in anti-tuberculosis immune response. Skewing of immunity from protective to pathogenic may involve a shift in Th1-Th2 paradigm. Cytokine gene polymorphism is known to be associated with functional differences in cytokine regulation and altered clinical performance in a variety of diseases. The aim of this study was to know whether Interle...

Background: chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease, those mechanisms are not fully understood. A significant role of cytokines, e.g., interleukin (IL)-1β, tumor necrosis factor (TNF) α, IL-10, IL-17А, IL-4, and their genes, in the pathogenesis predisposition to CRSwNP treatment efficacy established. Aim: investigate IL-1β (Т-31С), TNF-α (G-308A), IL-10 (G-...

The purpose of the work. To evaluate effectiveness use probiotic Alflorex and mesalazine in complex therapy patients with irritable bowel syndrome (IBS) diarrhea constipation, combined obesity, CT TT genotypes according to polymorphic variant C-159T CD14 gene. Materials methods. We examined 48 IBS associated obesity. In dynamics treatment we determined content serum C-reactive protein (CRP), tu...

Background Genetic polymorphisms in the endoplasmic reticulum aminopeptidase gene ERAP2 has been attributed with etiopathogenesis of ankylosing spondylitis (AS). Here we assessed association single nucleotide (SNPs) AS predisposition Iranian patients and determined their effect on inflammatory state patients. Methods For genotyping rs2548538, rs2287988, rs17408150 SNPs using a real-time allelic...

Inflammation is an important determinant of the severity and outcome of central nervous system injury. The endogenous anti-inflammatory cytokine interleukin-10 (IL-10) is upregulated in the injured adult central nervous system where it controls and terminates inflammatory processes. The developing brain, however, displays differences in susceptibility to insults and in associated inflammatory r...

Background: Obesity is associated with chronic inflammation in obese subjects, which leads to an increase of inflammatory cytokines. This study aimed to evaluate the effect of different intensity circuit resistance training on levels of interleukin 1 beta and interleukin-10 in obese men. Methods: In a semi-experimental trial during May to August 2020, 44 obese men from Tehran city were selecte...

To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared. The absence of IL-10 was associated with higher cytokine and chemokine concentrations and a more pronounced infiltrate, but antibacterial defense or survival was not...