This paper introduces the notion of “tangible business model sketches” – interactive sculpture-like mechanisms – to stimulate discussions concerning how businesses create and capture value. We outline the need for opening up discussions around innovation that these models address and their proposed utility for designers. We present three examples that model aspects of lighting design, audiology...

To determine the mechanism(s) responsible for glucocorticoid-induced increases in amylase content in pancreatic acinar AR42J cells, we examined the effects of dexamethasone on amylase protein biosynthesis, steady-state mRNA levels, and gene transcription. Dexamethasone treatment led to a dose-dependent increase in amylase synthesis which was one-half maximal at 2 nM and maximal at 100 nM where ...

Amylase activity variation in the guts of several model organisms appears to be explained by amylase gene copy number variation. We tested the hypothesis that amylase gene copy number is always elevated in animals with high amylolytic activity. We therefore sequenced the amylase genes and examined amylase gene copy number in prickleback fishes (family Stichaeidae) with different diets including...

We evaluated four kinetic amylase procedures with respect to kinetics, analytical range, blank rates, reagent stability, reagent impurities, interfering substances, and intrinsic sensitivities. Each of the methods is shown to have its own unique advantages and disadvantages. A preliminary discussion of some alternative methods, in which glycosidic p-nitrophenyl alpha-oligosaccharides are substr...

As a result of the importance acquired by the approach to the innovation systems in theory and policy,5,6 in recent years, the study of Innovation Intermediary Organisations (IIOs) has gained great interest. The OIIs are perceived as important agents in connecting knowledge supply and demand in the national systems of innovation (NSI).1 The authors highlight some functions that these organisati...

In addition to internal R&D, external knowledge is widely considered as an essential lever for innovative performance. This paper analyzes knowledge spillovers in supply chain networks. Specifically, we investigate how supplier innovation is impacted by buyer innovation. Financial accounting data is combined with supply chain relationship data and patent data for U.S. firms in high tech industr...

While usually been considered by established businesses as an attack, disruptive innovation provide an appropriate innovation approach for SMEs through new market discovery. This article tries to explore the opportunities offered by disruptive technlology and how SMEs could benefit from diruptive innovation. The process and features of diruptive innovaion and a managrial framework for diruptive...

the leopard moth, zeuzera pyrina, is a key and worldwide pest damaging walnut as well as many other fruit trees during the larval stages. larvae were collected from infested twigs of walnut trees. midguts from larvae were removed under a stereomicroscope and their homogenates used as the enzyme source. larval midgut extracts showed an optimum activity at ph 8.0, 6.0 and 6.0 for ?-amylase, ?- an...

We coupled a kinetic procedure to a selective inhibiting method for determining amylase isoenzymes in biological samples, using 4-nitrophenylmaltopentaoside plus 4-nitrophenylmaltohexaoside as substrate and a wheat-germ selective inhibitor with the Gilford S-III spectrophotometer. On plotting remaining amylase activities/total amylase activities (R/T) vs pancreatic amylase activities/salivary a...

Amylase expression in strain YBR differs in several respects from the standard mouse phenotype. The synthesis of salivary amylase is elevated twofold in YBR mice and the synthesis of pancreatic amylase is reduced to one-half the normal rate. We have compared the concentrations of amylase mRNA in the parotid, liver and pancreas of YBR mice with those in strains A/J and C3H. We observed differenc...