What do we mean when we talk about Supramolecular Chemistry? The easiest way to describe supramolecular chemistry is to consider the concept of “chemistry beyond the molecule”—We can think of supramolecular chemistry as more than the sum of the parts. In other words the way molecules interact and come together generates new and exciting properties that surpass those of the molecule. The very co...

The increasing importance of studies on soft matter and their impact on new technologies, including those associated with nanotechnology, has brought intermolecular and surface forces to the forefront of physics and materials science, for these are the prevailing forces in micro and nanosystems. With experimental methods such as the atomic force spectroscopy (AFS), it is now possible to measure...

In order to understand orientation-induced crystallization of polymers, we introduced an intermolecular interaction between polymer chains based on quantum mechanics. We therefore considered a pair of perfectly extended chains where the intermolecular interaction is assumed to be based on the hydrogen interaction with a single chain. When two protons of each extended chain become closer togethe...

Early Diagnosis of Cancers In article 2205445, Shangquan Wu, Qingchuan Zhang, and co-workers develop an ultra-sensitive nanomechanical sensor, which uses a magnetic-driven microcantilever array to selectively detect oncogenic exosomes. The magnetic force produces far greater deflection than that produced by the intermolecular interaction force, even in presence very low concentrations target su...

A force field for water has been developed entirely from first principles, without any fitting to experimental data. It contains both pairwise and many-body interactions. This force field predicts the properties of the water dimer and of liquid water in excellent agreement with experiments, a previously elusive objective. Precise knowledge of the intermolecular interactions in water will facili...

Recent advances in molecular force measurements have resulted in the quantification of the nanomechanical properties of single molecular bonds, and elucidated novel relationships between molecular architecture and biomolecular adhesion. The measured forces to rupture single intermolecular bonds revealed novel and unexpected ways that proteins respond to mechanical force. Measurement of the magn...

Intermolecular B-N coordination has been recognized as a promising driving force for molecular self-organization. However, direct utilization of this intermolecular interaction as building bridge for the supramolecular self-assembly of chemical functionalities to form nano-sized architectures remains a daunting challenge. Here, we outline a multiple intermolecular B-N coordination based supramo...

Intermolecular interactions involving pi-pi interaction and hydrogen bonding are used to create one-dimensional molecular nanostructures of hexasubstituted aromatics. Site-selective steady state fluorescence, time-resolved fluorescence, scanning electron microscopy, and atomic force microscopy measurements detail the intermolecular interactions that drive the aromatic molecules to self-assemble...

We present an approach to understanding crystal packing via 'energy frameworks', that combines efficient calculation of accurate intermolecular interaction energies with a novel graphical representation of their magnitude. In this manner intriguing questions, such as why some crystals bend with an applied force while others break, and why one polymorph of a drug exhibits exceptional tabletabili...