objective(s): nanoparticles (nps) are known for their specific accumulation in the inflamed tissues of the colon and thus allow a selective delivery to the site of inflammation with minimum adverse effects. the main objective of this work is to attain mesalamine loaded chitosan nanoparticles as a carrier for oral delivery. methods: in this study, mesalamine loaded chitosan nanoparticles were pr...

this review presents a brief outline of our current knowledge of the structure and chemical composition of the outer membrane vesicles (omvs), originating from the surface of gram negative bacteria including their outer membrane proteins and lipopolysaccharides. moreover, the functional roles and applications of omvs in medical research such as omv-based vaccines, omv adjuvants properties, omv ...

intravitreal injection is the most common approach for drug delivery to the posterior segment in humans. however, following the injection, drugs are rapidly eliminated from the vitreous, with half-lives up to a few days. depending on the rate of clearance from the vitreous, large boluses and frequent administrations may be required to ensure therapeutic levels over an extended period of time. m...

objective(s): in this research, zeolite x and zeolite y were used as vehicle to prepare intestine targeted oral delivery systems of indomethacin and ibuprofen. materials and methods: a soaking procedure was implemented to encapsulate indomethacin or ibuprofen within synthetic zeolites. gravimetric methods and ir spectra of prepared formulations were used to assess drug loading efficiencies into...

nowadays apphcanon of nanotubes in biology and medicinal science is more investigated. nanotubes can passthroueh cell walls and transport and release drugs in special tissues. the purpose of this paper is to investigatethe interaction of a nanotube having hydroxyl functional groups (oh) with an anticancer agent. in this worktransporting of an anticancer drug named 2-(2-amino 6,7-dimethyl pterid...

carvacrol is one of the main components of the eo of some labiatae (laminaceae) members like oregano, thyme and savory. carvacrol has a lot of health benefits for example, antibacterial, and antioxidant activity.we synthesized some silicon derivatives of carvacrol, and characterized them by standard methods. then the monomer of dimethylvinylsilyl carvacrol was synthesized. copolymer of this mon...

patient noncompliance to current tuberculosis (tb) therapy owing to multidrug administration daily leads to treatment failure and emergence of multidrug resistant and extensively drug resistant tb. to avoid the daily dosing, application of nanotechnology is the only viable solution by virtue of sustained release of drugs. other potential advantages of the system include the possibility of selec...

recent advances in nanotechnology have rapidly developed new therapeutic and diagnostic concepts in all aspects of medicine. magnetic nanoparticles (mnps) can be simultaneously functionalized and guided by a magnetic field, thus providing promising tools for several biomedical applications. mnps contrast agents at low concentrations offer the potential to significantly improve existing methods o...

Introduction Oral delivery is the most convenient and desired way for drug delivery. The major factor determinant for bioavailability of orally administered drug is the membrane permeability and drug solubility in the intestinal lumen. Many drugs show bioavailability problems due to their low water solubility, slow dissolution rate and instability in the gastrointestinal tract. One possibility ...

Oral controlled release and site specific drug delivery system has been of great interest in pharmaceutical field to achieve improved therapeutic advantage. Drug absorption in the gastrointestinal tract is a highly variable procedure and prolonging gastric retention of the dosage form extends the time for drug absorption. Gastro retentive drug delivery system is one of such novel approaches to ...