Intranasal route, ensuring suitable bioavailability of medicines under circumvention of the gastrointestinal degradation and hepatic first-pass elimination, has been a popular choice for drug delivery. Among nasal dosage forms, mucoadhesive solid inserts have been shown to resist mucociliary clearance and provide a prolonged nasal residence time. Hence, the purpose of this study was the prepara...

Intranasal drug delivery – which has been practiced for thousands of years, has been given a new lease of life. It is a useful delivery method for drugs that are active in low doses and show no minimal oral bioavailability such as proteins and peptides. One of the reasons for the low degree of absorption of peptides and proteins via the nasal route is rapid movement away from the absorption sit...

Ayurveda is the ancient medical system in India that uses nasal therapy. During COVID -19 pandemic, ministry of AYUSH providedguidelines to boost immunity. The Nasya (nasal delivery) was one recommendations by immunity.Nasya has been still practice for various ailments like chronic rhinitis, headache, cervical spondylosis, Dyspnea, etc., but theknowledge about how works unclear.This review arti...

This study investigates intra-cluster timing patterns in Russian obstruent-sonorant clusters as a function of their segmental composition. The results confirm for Russian a velar-nasal (/kn, gn/) vs. velar-lateral (/kl, gl/) timing difference like the one reported for German [2], but this could not be extended to labiallateral/nasal clusters (/vl, ml/ vs. /vn, mn/), which were all timed similar...

Over the recent decades the interest in intranasal delivery as a non-invasive route for drugs is increased.Since the nasal mucosa offers numerous benefits as a target tissue for drug delivery, a wide variety of therapeutic compounds may be administered intranasally for topic, systemic and central nervous system action. We have, herein, outlined the relevant aspects of nasal anatomy, physiology ...

AIMS OF STUDY We have previously demonstrated that early intra-nasal cooling improved post-resuscitation neurological outcomes. The present study utilizing a porcine model of prolonged cardiac arrest investigated the effects of intra-nasal cooling initiated at the start of cardiopulmonary resuscitation (CPR) on resuscitation success. Our hypothesis was that rapid nasal cooling initiated during ...