OBJECTIVES To observe the effect of the antioxidant lycopene on the occurrence of pre-eclampsia and intrauterine growth retardation in primigravida women. METHODS A total of 251 primigravida women were enrolled in this prospective, randomized controlled study in the second trimester. A total of 116 women were given oral lycopene (Group I) in a dose of 2 mg twice daily while 135 women were giv...

Overexpression of the conserved Ca(2+)-binding proteins calreticulin and calsequestrin impairs cardiac function, leading to premature death. Calreticulin is vital for embryonic development, but also impairs glucocorticoid action. Glucocorticoid overexposure during late fetal life causes intra-uterine growth retardation and programmed hypertension in adulthood. To determine whether intra-uterine...

Severe growth retardation of cattle early in life is associated with reduced growth potential, resulting in smaller animals at any given age. Growth potential diminishes as age of onset of nutritional restriction declines, and severe, prolonged intra–uterine growth retardation may result in slower growth of cattle throughout life. Severe weight loss during the months immediately after weaning o...

It has been shown that IGF-I has an anabolic effect in the normal fetus. However, there is evidence to suggest that there may be IGF-I resistance in the growth retarded fetus. Therefore, we investigated the effects of acute IGF-I infusion to chronically catheterised fetal sheep. At 128 days gestation, fetuses underwent a 4 h infusion of IGF-I (50 microg/kg/h). Three groups of animals were studi...

Transplacental transmission of rubella virus leads to Congenital Rubella Syndrome. It is comprised of congenital cardiac defects (most commonly patent ductus arteriosus), cataracts and sensorineural hearing loss. While prematurity and intra uterine growth retardation are frequent accompaniments of congenital rubella syndrome, at times birth weight can be normal. The possibility of fetal anomali...

background: the incidence of ectopic pregnancy varies between 1.5-2% of all pregnancies. bilateral tubal ectopic pregnancy is rare. it may occur in 1 per 200 000 pregnancies. case: this is a case report of 25 year-old woman who underwent intra uterine insemination (iui), because of tubal factor infertility (unilateral). on the 30pthp day after the iui she complained from pelvic pain and vaginal...