OBJECTIVE To present a case of intractable cryptogenic gelastic epilepsy with ictal video-EEG to localize the seizure focus. CLINICAL PRESENTATION AND INTERVENTION A 39-year-old female presented with a 2-year history of intractable gelastic epilepsy characterized by recurrent episodes of stereotyped pathological laughter, transient unresponsiveness, automatisms and brief postictal confusion. ...

To study the efficacy of vagus nerve stimulation (VNS) therapy as an adjunctive treatment for intractable epilepsy in patients under 12 years of age, we analyzed 2-year postimplant data of 35 consecutive patients. Of the 35 patients, 18 (51.4%) at 6 months, 18 (51.4%) at 12 months, and 21 (60.1%) at 24 months showed ≥50% reduction in seizure frequency (responders). Although incremental seizure ...

Catamenial epilepsy refers to a seizure pattern that coincides with the menstrual period. Patients catamenial often leads intractable and may have an adverse impact on quality of life. Several medications are therapeutic options, however, there is uncertainty regarding best treatment, these fail control seizure. This makes categorized as pharmaco-resistant epilepsy. paper reported case perimens...

Background: Epilepsy is the second common neurologic disorder. Although many antiepileptic drugs have been formulated to control the seizures, but not all seizures have been controlled by them. Uncontrolled epilepsy can actually reduce the patients’ quality of life. Objectives: Identifying the proportion of adult intractable epilepsy among epileptic patients in an area in the North East o...

High-grade gliomas (HGGs), including anaplastic astrocytoma and glioblastoma multiforme, are the most common primary brain tumors, and are often associated with seizures. Seizure control is a critical but often underappreciated goal in the treatment of patients harboring these malignant lesions. Patients with HGG who also have medically intractable seizures should be considered for a palliative...

objective the ketogenic diet is a high-fat, low carbohydrate, adequate protein diet,developed in the 1920s for the management of intractable seizure disorders in children. to evaluate efficacy and tolerability of the classic  ketogenic diet, we analyzed records of the children started on the diet from 1999 to 2006 at the mofid children's hospital.materials & methods   the subjects were 87 child...

OBJECTIVE Evaluate the seizure-reduction response and safety of brain-responsive stimulation in adults with medically intractable partial-onset seizures of neocortical origin. METHODS Patients with partial seizures of neocortical origin were identified from prospective clinical trials of a brain-responsive neurostimulator (RNS System, NeuroPace). The seizure reduction over years 2-6 postimpla...

PURPOSE Vagus nerve stimulation (VNS) therapy is a procedure to control seizure frequency in patients with medically intractable epilepsy. However, there is no data on efficacy in the subset of these patients with brain tumors. The purpose of this study is to evaluate the efficacy of VNS therapy in patients with brain tumor-associated medically intractable epilepsy. METHODS Data from the VNS ...

OBJECTIVE To determine the prognosis of seizures in epileptic children and identify early predictors of intractable childhood epilepsy. STUDY DESIGN Case-control study. PLACE AND DURATION OF STUDY The Epilepsy Centre of the Children's Hospital Lahore, from February 2005 to April 2007. PATIENTS AND METHODS All children (aged 1 month to 16 years) with idiopathic or cryptogenic epilepsy who ...