BACKGROUND Hepatic lesions in sickle cell disease were studied essentially in autopsy specimens. We investigated chronic hepatopathy in living adults with sickle cell disease and report the clinical, biochemical, and hepatic histological findings in these patients. METHODS A total of 170 adult patients with sickle cell syndrome were prospectively investigated. Clinical and laboratory investig...

T HE RELATIONSHIP between oxygen tension and the sickling phenomenon has been recognized for over 45 years’ and has become central to our thinking about sickle cell disease. It has been emphasized that sickling of red cells depends to a large degree upon the absolute concentration of reduced sickle hemoglobin.2 In the past two decades many therapeutic strategies have been explored in the manage...

In sickle cell trait (SCT), hemoglobin A (HbA) and S (HbS) are co-expressed in each red blood cell (RBC). While homozygous expression of HbS (HbSS) leads to polymerization and sickling of RBCs resulting in sickle cell disease (SCD) characterized by hemolytic anemia, painful vaso-occlusive episodes and shortened life-span, SCT is considered a benign condition usually with minor or no complicatio...

T HE RELATIONSHIP between oxygen tension and the sickling phenomenon has been recognized for over 45 years’ and has become central to our thinking about sickle cell disease. It has been emphasized that sickling of red cells depends to a large degree upon the absolute concentration of reduced sickle hemoglobin.2 In the past two decades many therapeutic strategies have been explored in the manage...

discussion the cholecystojejunocolic anastomosis with intussuscepted valve surgery could be considered as a forthcoming approach in the treatment of intrahepatic cholestasis. case presentation an 11-year-old girl with the diagnosis of pfic underwent cholecystoappendicostomy with myotomy operation. because of anastomosis stricture, she was reoperated with cholecystojejunocolic anastomosis and in...

T HE RELATIONSHIP between oxygen tension and the sickling phenomenon has been recognized for over 45 years’ and has become central to our thinking about sickle cell disease. It has been emphasized that sickling of red cells depends to a large degree upon the absolute concentration of reduced sickle hemoglobin.2 In the past two decades many therapeutic strategies have been explored in the manage...