Methods C56BL/6 mice were sensitized by intranasal administration of olive extract+cholera toxin B, for 6 weeks. Then, mice received immunotherapy (IT) treatment by subcutaneous (sc) injection of dendrimer-Ole1±50 mg of CpG, for 8 weeks. Seven days after the IT, mice were challenged with 100 mg of olive extract (ip). Severity of anaphylaxis was measured by drop in body temperature and the humor...

application of vasopressin fails to elicit changes in brain immediate early gene expression, neural activity and behavioral performance of rats' General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the l...

Previously, we reported the construction and characterization of a genetically defined Actinobacillus pleuropneumoniae (A. pleuropneumoniae) apxIIC gene mutant, HB04C(-), which conferred protection to mice against infection with A. pleuropneumoniae. In this study, we further evaluated HB04C(-) for safety and its ability to elicit protective immunity in pigs. It was demonstrated that a dose of 2...

Thygeson & Nataf (1958) stated, ‘It is now generally agreed that only primates are susceptible to experimental infection with trachoma virus ’. Since then Giroud, Renoux & Nataf (1958) have reported pulmonary hepatization in mice after intranasal inoculation of material from trachomatous conjunctivae; Hurst & Reeve (1960) reported passage of the TE55 strain in mouse brain; and Bernkopf (1959) r...

the objective of this study was to investigate the effect of intranasal phototherapy on nasal microbial flora in patients with allergic rhinitis. this prospective, self-comparised, single blind study was performed on patients with a history of at least two years of moderate-to-severe perennial allergic rhinitis that was not controlled  by  anti-allergic drugs.  thirty-one  perennial  allergic r...

In children pre-anaesthetic medications are frequently administered as pharmacological adjunctions to help alleviate the stress and fear of surgery as well as to ease child parental separation and promote a smooth induction. Oral, rectal, intravenous and intramuscular route has been used; however each route has its disadvantage. Pre-anaesthetic medication administered intranasal for avoidance o...

Transcutaneous immunization of mice with recombinant protective antigen (rPA) of Bacillus anthracis resulted in significantly higher lethal toxin-neutralizing antibody titers than did intramuscular injection of alum-adsorbed rPA. Immunized mice were partially protected against intranasal challenge with 235,000 (10 50% lethal doses) Ames strain B. anthracis spores. A highly significant correlati...

Avian pathogenic Escherichia coli (APEC) is a well-recognised pathotype that causes localised and systemic infections in avian species of all ages including eggs. To develop successful intervention strategies, a deep understanding of bacterial and host factors mediating crucial processes in pathogenesis is required. Such information can only be gathered through approaches that embrace infection...

OBJECTIVE To compare the pharmacokinetics, pharmacodynamics, and tolerability of USL261, a midazolam formulation optimized for intranasal delivery, versus midazolam intravenous (IV) solution administered intranasally (MDZ-inj IN) or intravenously (MDZ-inj IV) in healthy adults. METHODS In this phase 1, five-way crossover, open-label study, 25 healthy adults (aged 18-42 years) were randomly as...

We present an uncommon case of nasal alar and facial necrosis following calcium hydroxylapatite filler injection performed elsewhere without direct physician supervision. The patient developed severe full-thickness necrosis of cheek and nasal alar skin 24 h after injections into the melolabial folds. Management prior to referral included oral antibiotics, prednisone taper, and referral to a der...