The aim of this study was to determine the role of CC chemokine CCL6/C10 in acute inflammation. Intraperitoneal injection of thioglycollate increased peritoneal CCL6, which peaked at 4 h and remained elevated at 48 h. Neutralization of CCL6 significantly inhibited the macrophage infiltration (34-48% reduction), but not other cell types, without decreasing the other CC chemokines known to attrac...

Ultraviolet B (UVB) triggers lupus flare by worsening skin lesions and systemic symptoms, i.e. nephritis. We have reported that UVB exposure induces inflammation with neutrophil infiltration extracellular trap (NET) formation in mice. also found induced proteinuria young female lupus-prone The relevant mechanisms regarding dermal-renal crosstalk is unclear. examined lesions, proteinuria, of neu...

Liver fibrosis is the main pathological feature of various chronic liver diseases that can progress to cirrhosis. However, no effective treatment strategy for available. Phytic acid (PA) a natural plant compound found in cereals, legumes, and rapeseed. Currently, there are few reports on its relationship with fibrosis. Herein, we explored effects PA In this study, model was constructed by intra...

in this study, the effects of separate and combined intraperitoneal (ip) injections of histidine and dexamethasone were investigated on local inflammation in rats. local inflammation was induced by subcutaneous (sc) injection of histamine (100 μl, 0.1%) in ventral surface of right hind paw. the thickness of paw was measured at 30 min before and 30, 60, 90, 120, 150 and 180 min after injection o...

Introduction and Objective: liver is an important body organ without which life is impossible. Cyclophosphamide is an alkylating agent widely used as an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. The present study aimed to find a suitable antioxidant and examine the effect of vitamin E and selenium on reducing the side effects of cyclophosphamide on liver as a vit...

OBJECTIVES Allergic rhinitis (AR) is a chronic upper respiratory tract disease that inflames the mucous membranes of the nose and occurs when circulating inflammatory cells including eosinophils and basophils migrate to and accumulate in the inflammation area by passing through the interstitium and capillary walls. To pass through these barriers, the inflammatory cells degrade extracellular mat...

BACKGROUND: Neutrophil infiltration is one of the critical cellular components of an inflammatory response during peritonitis. The adhesion molecules, P-selectin and intercellular adhesion molecule (ICAM)-1, mediate neutrophil-endothelial cell interactions and the subsequent neutrophil transendothelial migration during the inflammatory response. Despite very strong preclinical data, recent clin...

results sixty patients completed the study. patients in the hydrocortisone group had no statistically significant abdominal and shoulder pain scores compared to the bupivacaine group. the patients were similar regarding postoperative analgesic requirements, return of bowel function, nausea and vomiting. no adverse effect was detected in either group. background postoperative pain is a major com...