A 39-year-old Caucasian woman with a history of recurrent conjunctival melanoma of her right eye developed an intrastromal heavily pigmented malignant melanoma, which involved the whole corneal diameter. The patient was treated by corneoscleral lamellar keratoplasty and there has been no evidence of recurrent neoplasm during 4 years of follow-up. This apparently unique presentation of malignant...

Keratoconus management has significantly changed over the last two decades. The advent of new interventions such as cornea cross-linking, intrastromal corneal ring segments, and combined treatments provide corneal clinicians a variety of treatment options for the visual rehabilitation of keratoconus patients. This review summarizes current evidence for these treatments and highlights their plac...

It remains elusive as to what bone marrow (BM) cell types infiltrate into injured and/or diseased tissues and subsequently differentiate to assume the phenotype of residential cells, for example, neurons, cardiac myocytes, keratocytes, etc., to repair damaged tissue. Here, we examined the possibility of whether BM cell invasion via circulation into uninjured and injured corneas could assume a k...

purpose : to present the clinical features, biomechanical properties and management of a patient who developed unilateral corneal ectasia after photorefractive keratectomy (prk) case report : the patient was a 24-year-old man without any obvious preoperative risk factor for ectasia who underwent bilateral prk. four years after keratorefractive surgery, the patient presented with loss of visual ...

Corneal ectasia is a serious complication of laser in situ keratomileusis (LASIK). We report the case of a 29-year-old man who underwent LASIK in both eyes and in whom corneal ectasia developed in the left eye 3 years after surgery. He was treated sequentially with intraocular pressure-lowering medication, intrastromal corneal ring segment (ICRS) implants, and collagen cross-linking. Vision imp...

In this review, we analyzed the domestic and foreign literature on use of corneal lenticula obtained by keratorefractive surgery using SMILE technology (SMall Incision Lenticula Extraction). Research is being actively carried out a lenticular tissue for refractive purposes: correction hyperopia (LIKE – Lenticular Intrastromal Keratoplasty), presbyopia (PEARL PrEsbyopic Allogenic Refractive Lent...

Previous studies demonstrated that in the murine model of Onchocerca volvulus keratitis, neutrophils and eosinophils are recruited into the cornea in a biphasic manner in response to intrastromal injection. To determine if CD4(+) T cells regulate migration of neutrophils and eosinophils into the cornea, CD4(+) cells were depleted using monoclonal antibody GK1.5 before intrastromal injection of ...

OBJECTIVE To compare the therapeutic effectiveness of a single intrastromal dose of gentamycin, tobramycin, ciprofloxacin and ofloxacin for the treatment of corneal ulcers due to Pseudomonas aeruginosa. METHODS Twelve white female New Zealand rabbits underwent mechanical removal of corneal epithelium; then one drop of salt suspension containing Pseudomonas aeruginosa (75,000,000 colony formin...

The use of a laser in place of a mechanical keratome for flap creation was a turning point in the field of refractive surgery. Visible and near infrared laser light are absorbed by the refractive structures of the eye and allowed to pass freely into the eye without effect at low-power densities. At high-power densities, the nonlinear optical properties of the cornea lead to absorption, generati...