Good morning Senator Specter, Senator Harkin, and Members of the Subcommittee. I am Richard Klausner, Director of the National Cancer Institute (NCI), and today I am presenting to you, for the first time, the completed NCI report estimating thyroid doses of Iodine-131 (I-131) received by Americans as a result of atmospheric nuclear bomb tests conducted at the Nevada Test Site. This study was co...

Objective To explore the therapeutic response (TR) and long-term outcomes of iodine-131 (I-131) treatment for patients with differentiated thyroid cancer and pulmonary metastases (DTC+PM), as well as the association between the assessment of TR and long-term outcomes. Methods This retrospective study comprised 151 DTC+PM patients. TR was evaluated by changes in serum levels of thyroglobulin, ...

Sodium Iodide-131 is administrated for treatment of hyperthyroidism and thyroid cancer. Iodine-131 has multiple routs of excretion (Urine, saliva, sweat, milk, feces, exhalation) from the body. Patients receiving Sodium Iodide-131 therapy exposes other persons and the environment to unwanted radiation and contamination. The major source of radiation dose from administration of Iodine-131 ...

Graves' disease is a thyroid-specific autoimmune disorder in which the body makes antibodies to the thyroid-stimulating hormone receptor leading to hyperthyroidism. Therapeutic options for the treatment of Graves' disease include medication, radioactive iodine ablation, and surgery. Radioactive iodine is absolutely contraindicated in pregnancy as exposure to I-131 to the fetal thyroid can resul...

BACKGROUND The increased incidence of autoimmune thyroid disease with increasing dietary iodine intake has been demonstrated both epidemiologically and experimentally. The hypothyroidism that occurs in the first year following radioactive iodine therapy is probably related to the destructive effects of the radiation and underlying ongoing autoimmunity. OBJECTIVE To study the outcomes at the e...

[This corrects the article DOI: 10.1371/journal.pone.0172312.].

BACKGROUND Iodine 131 ablation following total thyroidectomy is considered an indispensable element of successful treatment of differentiated thyroid carcinoma (Dtc). because of the essential role of the kidneys in iodine clearance, (131)I therapy of Dtc in patients with end stage renal disease, particularly those maintained on haemodialysis, present a number of special features: the (131)I act...

In a recent report (1), List, Telegadas, and Ferber take issue with my earlier conclusion (2) that vented underground tests in Nevada were the probable sources for the repeated occurrences of iodine-131 fallout in midwestern United States during May 1962. In doing so they provide no evidence to establish that the underground shots in question were contained, but they suggest that precipitation ...

BACKGROUND The goal of iodine-131 therapy for pediatric Graves' disease is to induce hypothyroidism. However, changes in post-treatment thyroid volume have not been investigated in pediatric and/or adolescent patients. OBJECTIVE The aim of this retrospective study was to examine whether changes in thyroid volume predict post-treatment hypothyroidism in adolescent Graves' disease patients. P...