Yellow-related proteins (YRPs) present in sand fly saliva act as affinity binders of bioamines, and help the fly to complete a bloodmeal by scavenging the physiological signals of damaged cells. They are also the main antigens in sand fly saliva and their recombinant form is used as a marker of host exposure to sand flies. Moreover, several salivary proteins and plasmids coding these proteins i...

background: sand fly saliva helps parasite establishment and induce immune responses in vertebrate hosts. in the current study, we investigated the modulation of phlebotomus papatasi salivary gland antigen expression by sea­sonal and biological factors. methods: sand flies were grouped according to physiological stages such as unfed, fed, semi-gravid, gravid, parous, nulliparous, infected or no...

INTRODUCTION Sand fly saliva plays an important role in both blood feeding and outcome of Leishmania infection. A cellular immune response against a Phlebotomus papatasi salivary protein was shown to protect rodents against Leishmania major infection. In humans, P. papatasi salivary proteins induce a systemic cellular immune response as well as a specific antisaliva humoral immune response, mak...

a total of 1,497 serum and blood specimens from residents of 18 different iranian communities were examined by plaque reduction neutralization test for antibodies against four (neaples, sicilian, karimabad and salehabad) phlebotomus fever virus serotypes. neutralizing antibodies against the naples and sicilian serotypes were found in every community sampled, indicating that these viruses are wi...

BACKGROUND Cutaneous leishmaniasis is a neglected, vector-borne parasitic disease and is responsible for persistent, often disfiguring lesions and other associated complications. Leishmania, causing zoonotic cutaneous leishmaniasis (ZCL) in the Old World are mainly transmitted by the predominant sand fly vector, Phlebotomus papatasi. To date, there is no efficient control measure or vaccine ava...

background: visceral leishmaniasis (vl) is one of the most important parasitic zoonotic diseases in the world. do­mestic dogs are the main domestic reservoirs of vl in endemic foci of iran. various methods, including vaccination, treatment of dogs, detection and removal of infected dogs have different results around the world. general policy on control of canine visceral leishmaniasis is protec...

objective: ajowan is an annual herbaceous essential oil of carum copticom. the main components of the oil are tymol, β-pinene, γ- terpinene and sabinene.the fruit oil of carum copticum has been reported to have several therapeutic effects including anti fungal, anti bacterial and anti viral,... candida albicans is an opportunistic fungus and transforms into pathogenic form in favorable conditio...

Phlebotomine sand flies are vectors of Leishmania that are acquired by the female sand fly during blood feeding on an infected mammal. Leishmania parasites develop exclusively in the gut lumen during their residence in the insect before transmission to a suitable host during the next blood feed. Female phlebotomine sand flies are blood feeding insects but their life style of visiting plants as ...

Cutaneous leishmaniasis is a sand fly-transmitted disease characterized by skin ulcers that carry significant scarring and social stigmatization. Over the past years, there has been cumulative evidence that immunity to specific sand fly salivary proteins confers a significant level of protection against leishmaniasis. In this study, we used an attenuated strain of Listeria monocytogenes as a va...

BACKGROUND Leishmaniases are parasitic diseases present worldwide that are transmitted to the vertebrate host by the bite of an infected sand fly during a blood feeding. Phlebotomine sand flies inoculate into the mammalian host Leishmania parasites embedded in promastigote secretory gel (PSG) with saliva, which is composed of a diverse group of molecules with pharmacological and immunomodulator...