BACKGROUND Irritable bowel syndrome is one of the most commonly encountered gastrointestinal disorders, for which there are no established diagnostic criteria. Thus, a diagnosis of IBS is made by exclusion of any organic diseases. Recently, important attempts for the positive diagnosis of irritable bowel syndrome by questionnaire surveys of physical symptoms have been made. We performed a quest...

1. Small bowel dysmotility may be one of the clinical manifestations in Occidental patients with irritable bowel syndrome. Here we studied the characteristics of small bowel motility in Oriental patients with irritable bowel syndrome and identified the factors responsible for disturbed small bowel motility. 2. We enrolled 90 patients with irritable bowel syndrome and 45 healthy controls to the ...

BACKGROUND AND PURPOSE Functional neuroimaging studies in irritable bowel syndrome have revealed abnormalities in the corticolimbic regions, specifically, hyperactivity of the amygdala during visceral and somatic stimulation. This study investigated changes in the neural circuitry of the amygdala in patients with irritable bowel syndrome based on resting-state functional connectivity. MATERIA...

background: improving life is the main goal of therapeutic interventions for chronic diseases. although we needed to determine quality of life by various variables. this study aimed to determine quality of life in patients with irritable bowel syndrome (ibs) in kerman. materials and methods: this is a cross sectional study of 143 patients with ibs referred to a specialist, assessed by ibs-qol.3...

background: celiac disease (cd) may be misdiagnosed as irritable bowel syndrome (ibs) resulting in long delays in diagnosing cd. there are contradictory reports on the association of cd with ibs.appropriateness of screening all patients with ibs for cd and how to screen them are still under question. materials and methods: in a cross-sectional study, 328 ibs patients (rome ii) referred to the p...

Studies have shown that familial aggregation is of importance for abdominal symptoms including irritable bowel syndrome and there are a few reports of a moderate heritability for irritable bowel syndrome. Sex differences in prevalence and incidence of irritable bowel syndrome have been demonstrated however less is known about sex differences in heritability. The objective was to investigate whe...

BACKGROUND ONO-2952 is a novel and selective inhibitor of translocator protein 18 kDa that reduces stress-induced defecation and visceral hyperalgesia in rat models. AIM To evaluate the efficacy and safety of ONO-2952 in females with irritable bowel syndrome with diarrhoea in an exploratory proof-of-concept study. METHODS A randomised, double-blind, placebo-controlled study was conducted at...

BACKGROUND Abnormalities of gut motility and visceral pain perception are both thought to be involved in the pathogenesis of irritable bowel syndrome and may be susceptible to modulation by drugs affecting the various 5-HT receptor subtypes. The aim of this study was to investigate the therapeutic potential of a 5-HT3 antagonist in irritable bowel syndrome. METHODS Fifty patients with irritab...

INTRODUCTION Irritable bowel syndrome is a common functional gastrointestinal disorder. Although its aetiology is still unknown, visceral hypersensitivity, disorders of motility and psychosocial factors have been proposed as possible factors that affect the "gut-brain" function. The objective of this study was to determine if psychiatric disorders exist in patients with irritable bowel syndrome...

AIM The aim of this study was to assess the incidence of irritable bowel syndrome in women undergoing hysterectomy and tubular ligation. BACKGROUND The results of previous studies have shown an increased incidence of irritable bowel syndrome after gynecological surgeries. PATIENTS AND METHODS Participants were patients of Alzahra and Taleghani University hospitals in Tabriz. One hundred and...