A congenital mesenteric defect in an adult is very rare, but can cause internal hernia with small bowel obstruction. Awareness of defects important to the general surgeon when faced acute abdominal condition. We report a case 40-year-old man who presented emergency department pain. An X-ray revealed multiple air fluid levels dilatation and large bowels suggestive obstruction or ischaemia, perfo...

Objective Acute mesenteric ischaemia leads to intestinal damage. Restoration of blood flow results in further damage to tissue, which is called reperfusion injury. This study aimed to investigate the protective effects of short-interval postconditioning and to determine the optimal interval for reperfusion in an experimental rat model of intestinal ischaemia. Methods Forty adult male Wistar rat...

AIMS Unfavourable cardiac remodelling often complicates acute myocardial infarction (AMI) as a result of increased cardiomyocyte apoptosis. It is currently unclear whether ongoing or recurrent ischaemia is an independent determinant for increased apoptosis in peri-infarct viable myocardium. METHODS AND RESULTS In order to assess the link between infarct-related artery (IRA) occlusion, ischaem...

Background Restoration of blood supply to the heart after a prolonged ischaemic episode causes myocardial ischaemia-reperfusion (I/R) injury. Paradoxically, short periods of ischaemia and reperfusion, known as preconditioning, has a potent cardioprotective effect. One key aspect of I/R injury is cytotoxic mitochondrial fission that allows cytochrome c release and promotes apoptotic cell death. ...

OBJECTIVE The cytokine cardiotrophin-1 (CT-1) has previously been shown to protect cultured cardiocytes from cell death induced by serum removal or hypoxia when administered prior to the damaging stimulus. We wished to test whether a similar protective effect could be observed if CT-1 was added after the ischaemic period and to investigate the signalling pathways involved in the protective effe...

OBJECTIVE Nuclear imaging data demonstrate that revascularisation leads to favourable effects on ischaemia burden and improved outcomes compared with medical therapy (MT). In patients with heart failure (HF), the effects of MT versus revascularisation on ischaemia change and its independent prognostic significance requires investigation. METHODS From the Duke Databank, we performed a retrospe...

OBJECTIVE To examine the effect of handgrip exercise induced ischaemia on non-invasive assessment of endothelial function in the brachial artery. DESIGN AND SETTING High frequency ultrasound was used to measure brachial artery diameter at rest and after reactive hyperaemia induced by forearm cuff occlusion with and without handgrip exercise induced ischaemia. SUBJECTS 10 healthy subjects, <...

Global myocardial ischaemia improves intracardiac operating conditions but damages the myocardium. Propranolol should reduce this damage but may impair postoperative myocardial contractility. An assessment of its protective effect during 90 minutes of normothermic ischaemia in canine hearts has been made. The early and late changes of contractility caused by low-dose propranolol were also recor...