Objective: Ischemia-reperfusion (I-R) injury is defined as the paradoxical exacerbation of cellular dysfunction and death following restoration blood flow to ischemic tissues. In our study, it was aimed examine potential DNA effects liver IR with an experimental animal model. Material Methods: modeling done seven male New Zealand rabbits. Blood samples were taken before model, 30 minutes after ...

Myocardial infarction is a common presentation of coronary artery disease and the leading cause of death worldwide. The present study was investigated potential resistance to ischemia-reperfusion (I/R) injuries following administration of methanolic (MeOH) extract of Scrophularia frigida (S. frigida) in isolated rat heart. Male Wistar rat hearts (n= 8-10) were isolated and allowed to equilibrat...

Remote ischemic preconditioning reduces myocardial infarction (MI) in animal models. We tested the hypothesis that the systemic protection thus induced is effective when ischemic preconditioning is administered during ischemia (PerC) and before reperfusion and examined the role of the K(+)-dependent ATP (K(ATP)) channel. Twenty 20-kg pigs were randomized (10 in each group) to 40 min of left ant...

The effect of melatonin on reperfusion arrhythmias and postischemic contractile dysfunction was studied in the isolated rat heart. 25 min global ischemia was induced and followed by 30 min of reperfusion. Melatonin (10 micromol/l) was present in the perfusion solution during the whole experiment. Experiment revealed protective effect of melatonin on reperfusion-induced arrhythmias--arrhythmia s...

hepatic ischemia-reperfusion (i/r) is a common phenomenon during liver surgery, transplantation, infection and trauma which results in damage and necrosis of the hepatic tissue through different pathways. mechanisms involved in i/r damage are very intricate and cover several aspects. several factors are involved in i/r-induced damages; briefly, decrease in sinusoidal perfusion and atp generatio...

objective: it is generally agreed that most of the phenomena observed during brain ischemia and reperfusion can be explained by the damage to membrane structure. oxidative stress is resulted in an imbalance between high consumption of oxygen and low levels of endogenous antioxidants. it is known that gallic acid (ga) is a strong antioxidant. the present study was carried out to evaluate the eff...

An ischemia-reperfusion (I/R) injury of small intestine is a serious and common condition that result the blockage superior mesenteric artery (SMA) because significant clinical problems. This study evaluated effect Mesna on systemic induced by ischemia/reperfusion (IR) in also liver, kidney lung as remote organs. Forty Wistar albino rats were randomly divided into four groups: control, ischemia...

objective: several studies have shown that chichorium intybus l. (c. intybus) which possesses flavonoid compounds has an effective role in treatment of cardiovascular diseases. contractile dysfunction mostly occurs after acute myocardial infarction, cardiac bypass surgery, heart transplantation and coronary angioplasty. the aim of the present study was to investigate the effect of aqueous extra...

background: the aim of this study was to investigate the protective effects of crocin against tissue damages and leukocyte infiltration induced by renal ischemia/reperfusion. methods: in this experimental study, 35 male wister rats weighing 250-300 g were randomly divided into 5 groups; 1. operated controls, but no vessel occlusion was considered and passed during equivalent reperfusion period ...