Introduction: Postoperative neurological deficit is the most devastating complication after thoracoabdominal aortic aneurysm repair. Despite demonstrated neuroprotective effects of estradiol, its protective efficacy against spinal cord ischemia-reperfusion and underlying mechanisms are not yet elucidated. Methods: Two groups, each of 10 New Zealand white male rabbits, were studied. Control g...

Preconditioning may find ready applicability in humans facing scheduled global cardiac ischemiareperfusion (IR) during bypass or transplantation, where such a maneuver is feasible before arrest. Our objective was to delineate and exploit the endogenous preconditioning mechanism triggered by transient ischemia (TI) and thereby attenuate myocardial postischemic mechanical dysfunction by clinicall...

Kinsey GR, McHowat J, Beckett CS, Schnellmann RG. Identification of calcium-independent phospholipase A2 in mitochondria and its role in mitochondrial oxidative stress. Am J Physiol Renal Physiol 292: F853–F860, 2007. First published October 17, 2006; doi:10.1152/ajprenal.00318.2006.—Oxidant-induced lipid peroxidation and cell death mediate pathologies associated with ischemiareperfusion and in...

Riyad T. Ellati, Parviz K. Kavoussi, Terry T. Turner, Jeffrey J. Lysiak From the Department of Urology, University of Virginia Health System, USA Purpose: This review addresses different aspects of testicular torsion from the clinical perspective as well as the basic cellular and molecular events responsible for the post-torsion testicular changes and pathology, including tissue ischemia-reperf...

NIKOLIC-HEITZLER, V., RABUZIN, F., TATZBER, F., VRKIC, N., BULJ, N., BOROVIC, S., WONISCH, W., SUNKO, B.M. and ZARKOVIC, N. Persistent Oxidative Stress after Myocardial Infarction Treated by Percutaneous Coronary Intervention. Tohoku J. Exp. Med., 2006, 210 (3), 247-255── Acute myocardial infarction causing cardiac ischemia is responsible for the majority of cardiac related deaths. Medical inte...

Signal transducer and activator of transcription (STAT) 3 is involved in mediating a broad range of biological processes, including cell survival, proliferation, and immune response. Recent evidence has indicated that STAT3 in cardiomyocytes can be activated by ischemic-oxidative stress and exerts cardioprotection in the ischemic heart. There is no information, however, regarding the effect of ...

With the advances in percutaneous coronary intervention technology and accompanying medical therapy, the prognosis of patients with acute coronary syndromes has greatly improved over the last decades. Still, approximately 6% of admitted patients do not survive to hospital discharge,1 and despite the implementation of rapid interventional protocols, loss of cardiac tissue, and a consecutive decr...