نتایج جستجو برای: ischemic kidney injury
تعداد نتایج: 573979 فیلتر نتایج به سال:
BACKGROUND Remote ischemic preconditioning is a simple therapy that may reduce cardiac and kidney injury. We undertook a randomized controlled trial to evaluate the effect of this therapy on markers of heart and kidney injury after cardiac surgery. METHODS Patients at high risk of death within 30 days after cardiac surgery were randomly assigned to undergo remote ischemic preconditioning or a...
Ischemia-reperfusion injury (IRI) is the major cause of acute kidney injury. Remote ischemic conditioning (rIC) performed as brief intermittent sub-lethal ischemia and reperfusion episodes in a distant organ may protect the kidney against IRI. Here we investigated the renal effects of rIC applied either prior to (remote ischemic preconditioning; rIPC) or during (remote ischemic perconditioning;...
global cerebral ischemia (gci) and reperfusion induced apoptosis that lead to cell injury and death. the bax and bcl-2 are pro-apoptotic and anti-apoptotic genes, respectively. these genes belong to the b-cell lymphoma-2 (bcl-2) family.in this study; we assessed the effect of pentoxifylline drug on bax/bcl2 gene dosage expression changes following ischemic reperfusion injury in kidney. in thi...
Ischemia followed by reperfusion contributes to the initial damage to allografts after kidney transplantation (ktx). In this study we tested the hypothesis that a tetrapeptide EA-230 (AQGV), might improve survival and attenuate loss of kidney function in a mouse model of renal ischemia/reperfusion injury (IRI) and ischemia-induced delayed graft function after allogenic kidney transplantation. I...
We thank Wei and colleagues for their interest 1 in our report 2 on the susceptibility of diabetic models to renal ischemia-reperfusion injury (IRI) that involves hyperglycemia, p53 and mitochondrial pathway of apoptosis. We agree that reactive oxygen species (ROS) might be an important factor for heightened p53 activation by IRI in diabetic kidneys. ROS is produced in diabetic tissues and may ...
Zuk, Anna, and Karl S. Matlin. Induction of a laminin isoform and 3 1-integrin in renal ischemic injury and repair in vivo. Am J Physiol Renal Physiol 283: F971–F984, 2002. First published July 16, 2002; 10.1152/ajprenal.00176. 2002.—Ischemic injury to the kidney, a major cause of acute renal failure, leads to the detachment and loss of numerous tubular epithelial cells. Integrin-laminin intera...
ACUTE KIDNEY INJURY (AKI) is the abrupt loss of kidney function leading to the retention of nitrogenous waste products and perturbations in fluid and electrolyte balance. AKI has occurred historically in up to 7% of hospitalized patients and is associated with increased mortality, longer lengths of stay in the hospital, and increased costs of care (4, 12). Due to the aging of the population in ...
TLRs are an evolutionarily conserved family of cell membrane proteins believed to play a significant role in innate immunity and the response to tissue injury, including that induced by ischemia. TLR signaling pathways activate transcription factors that regulate expression of prosurvival proteins, as well as proinflammatory cytokines and chemokines through one of two proximal adapter proteins,...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید