نتایج جستجو برای: ischemic white matter
تعداد نتایج: 450059 فیلتر نتایج به سال:
white matter lesions (wmls) are commonly observed in strokepatients with small vessel disease (svd) and are thought toresult from a progressive, irreversible disease process followingarteriolosclerosis. in this study, we report a case of partialdisappearance of wmls 1 year after a lacunar stroke in a69-year-old man with evidence of svd. we also discuss possiblemechanisms associated with this ob...
Posterior reversible encephalopathy syndrome (PRES) typically affects the posterior subcortical white matter. We report the case of a 55-year-old man with atypical PRES, who had malignant hypertension and renal dysfunction. Magnetic resonance imaging of the brain revealed extensive vasogenic edema in the deep white matter including the temporal pole, as well as in the brainstem and cerebellum. ...
BACKGROUND AND PURPOSE Chronic cerebral hypoperfusion can lead to ischemic white matter injury resulting in vascular dementia. To characterize white matter injury in vascular dementia, we investigated disintegration of diverse white matter components using a rat model of chronic cerebral hypoperfusion. METHODS Chronic cerebral hypoperfusion was modeled in Wistar rats by permanent occlusion of...
The major pathological correlate of cerebral palsy is ischemic injury of CNS white matter. Histological studies show early injury of glial cells and axons. To investigate glial cell injury, I monitored intracellular Ca2+ and cell viability in fura-2-loaded neonatal rat white matter glial cells during ischemia. Fura-2 fixation combined with immunohistochemistry revealed that fura-2-loaded cells ...
Diffuse changes in white matter resulting from cerebral microvascular disease contribute to cognitive impairment (Jokinen et al., 2011), declines in global functionality (Inzitari et al., 2009), and even death (Debette and Markus, 2010). Twenty years ago, estimations of the clinical incidence of cerebral microvascular disease approached 11 million per year in the US alone (Leary and Saver, 2003...
BACKGROUND AND PURPOSE Enlarged perivascular spaces in the brain are common but generally overlooked and of uncertain pathophysiology. They may reflect underlying cerebral small vessel disease. We determined whether enlarged perivascular spaces were associated with lacunar stroke subtype and white matter hyperintensities, markers of established small vessel disease. MATERIALS AND METHODS We p...
BACKGROUND AND PURPOSE Information on the neuropathological changes underlying ischemic leukoaraiosis is only available postmortem, and there are limited data on histological appearances early in the disease. Diffusion tensor imaging allows determination of the directionality of diffusion, which is greater in the direction of white matter bundles. Therefore, the technique might be expected to s...
Normal Brain Aging and its Risk Factors –Analysis of Brain MRI Database of Healthy Japanese Subjects
We collected brain MRIs of 2,000 healthy Japanese and constructed an MRI database together with their characteristics such as age, sex, blood pressure, present and past disease history and cognitive functions. Volumetric analysis revealed that gray matter volume linearly decreased with time, while white matter volume remained unchanged during aging. Based on the regression line for gray matter ...
UNLABELLED The aim of this study was to determine the relationship between meningitis and neonatal period of complications such as massive intraventricular hemorrhage and into brain tissue, hypoxic-ischemic white matter injury retinopathy of prematurity 3-5 degrees and deafness in infants born prematurely from single and multiple pregnancies. MATERIAL The retrospective study covered 460 prete...
OBJECTIVE Rare mitochondrial mutations cause neurologic disease, including ischemic stroke and MRI white matter changes. We investigated whether common mitochondrial genetic variants influence risk of sporadic ischemic stroke and, in patients with stroke, the volume of white matter hyperintensity (WMHV). METHODS In this multicenter, mitochondrial genome-wide association study (GWAS), 2284 isc...
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