نتایج جستجو برای: isobologram
تعداد نتایج: 212 فیلتر نتایج به سال:
The synergistic activities of netilmicin, gentamicin and amikacin combined with carbenicillin, ticarcillin, azlocillin and mezlocillin were investigated against 32 Serratia marcescens isolates. Synergy could be demonstrated by killing curve technique, isobologram plots as susceptibility data with any of the aminoglycosides and penicillins combinations. No antagonism was shown with any of the co...
BACKGROUND We have recently completed a large phase III trial in advanced non-small cell lung cancer (NSCLC) in the elderly which showed that the combination of gemcitabine (GEM) plus vinorelbine (VNR), with GEM administered first, did not improve any outcome as compared with each single drug. MATERIALS AND METHODS The anti-tumor efficacy of different sequences of administration of GEM and VN...
This study evaluated the combination interactive effects of G. latifolium leaves and P. nitida seed extracts using a metabolic glucose tolerance test. The plant samples were extracted separately cold maceration their acute toxicities determined. Dose-response tolerant tests both plants done 2 g/kg load monitored over 0 – 1h. A 41% effect isobologram was used to determine needed dose combination...
Artemisinin is a powerful drug that has been combined with other antimalarial drugs to combat malaria and it crucial recent achievements in reducing cases. However, the emergence of Plasmodium falciparum resistance against artemisinin become serious problem treatment. Our previous studies reported alkalinised digestive vacuole P. similarly concanamycin A. Concanamycin A specific inhibitor V-typ...
A generalized method for analyzing the effects of multiple drugs and for determining summation, synergism and antagonism has been proposed. The derived, generalized equations are based on kinetic principles. The method is relatively simple and is not limited by whether the dose-effect relationships are hyperbolic or sigmoidal, whether the effects of the drugs are mutually exclusive or nonexclus...
PURPOSE The present study investigated the possible synergistic inhibitory effect of a novel combination of polyphenon E (PPE, a standardized green tea polyphenol preparation) and atorvastatin (trade name Lipitor) in a mouse tumorigenesis model and in human lung cancer H1299 and H460 cell lines. EXPERIMENTAL DESIGN Female A/J mice were given two weekly i.p. injections of 4-(methylnitrosaminao...
Introduction Ursolic acid (UA) is a pentacyclic triterpene acid present in many plants, including apples, basil, cranberries, and rosemary. UA suppresses proliferation and induces apoptosis in a variety of tumor cells via inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB). Given that single agent therapy is a major clinical obstacle to overcome in the treatment ...
Colorectal cancer (CRC) is among the most commonly occurring cancers. The management of CRC includes laparoscopic surgery, radiotherapy, chemotherapies and neoadjuvant treatment. However, conventional have poor impact on combating are associated with severe toxic effects high rates relapse. Therefore, searching for a new combination regimen favorable consideration. aim this study was to elucida...
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