Reference models such as ITIL and COBIT (Control Objectives for Information and related Technology) represent proven best practices and provide key indicators for the design and control of ITSM processes. The idea behind the development of ITIL is the recognition that organizations are becoming increasingly dependent on IT in order to satisfy their corporate aims and to meet their business need...

Deutsche Hochschulrechenzentren beschäftigen sich derzeit immer mehr mit der Umsetzung von IT-Servicemanagement (ITSM). Erste Schritte sind die Etablierung einzelner ITSM-Prozesse, wie Incident Management und damit verbunden die Einführung eines Service Desk als Single Point of Contact sowie die Umsetzung der Prozesse mit entsprechenden ITSMSystemen. Um mehr Transparenz bezüglich Zuständigkeite...

We examine intraday time series momentum (ITSM) in an international setting by employing high-frequency data of 16 developed markets. show that ITSM is economically sizable and statistically significant both in- out-of-sample most countries. Based on theories investor behavior, we propose test four hypotheses to reveal the source profitability. document cross-section dimension stronger when liq...

Zusammenfassung Zur Erbringung verschiedenster IT-Service-Management (ITSM)-Prozesse setzen insbesondere Großunternehmen seit Längerem umfangreiche ITSM-Software-Suiten ein. Im Rahmen ihrer Digitalisierungsinitiativen sind sie gegenwärtig verstärkt auf der Suche nach einem ergänzenden Self-Service-Portal. Damit können sich Mitarbeiter in erster Linie über die angebotenen IT-Services informieren...

Triggering of 2B4 (CD244) can induce natural killer (NK)-cell activation, costimulation, or even inhibition of NK-cell activity. Here, we investigate the molecular basis for the different signals generated by 2B4. We show that the first immunoreceptor tyrosine-based switch motif (ITSM) within the cytoplasmic tail of 2B4 is sufficient for 2B4-mediated NK-cell activation, whereas the third ITSM c...

To study the cis- and trans-acting factors that mediate programmed death 1 (PD-1) signaling in primary human CD4 T cells, we constructed a chimeric molecule consisting of the murine CD28 extracellular domain and human PD-1 cytoplasmic tail. When introduced into CD4 T cells, this construct mimics the activity of endogenous PD-1 in terms of its ability to suppress T cell expansion and cytokine pr...

Organizations are implementing IT Service Management (ITSM) and creating quality standards to design, deliver, and manage IT services to meet or exceed an agreed level of quality. ITSM uses the best practices of IT Infrastructure Library (ITIL) that informs IT management what needs to be done and how it will get done from the process perspective. However when undertaking an ITSM a project to im...

Universities have a responsibility to equip graduates with the knowledge and skills to be productive in their work environment. Recently, the discipline of IT Service Management (ITSM) has become globally recognized as critical to organizations. Academia appears to be lagging industry in providing education in this field. This paper describes the motivation, implementation, outcomes and challen...