Ivermectin was evaluated as a potential rodent feed-through for the control of immature stages of Phlebotomus papatasi. The survival of sand fly larvae fed feces of Syrian hamsters (Mesocricetus auratus) that had been fed a diet containing 0, 2, 6, 10, 20, 60, or 100 ppm ivermectin was measured. Sand fly larvae fed the feces of ivermectin-treated hamsters had significantly reduced survival, wit...

The study aim to develop simple, sensitive, rapid, accurate and precise spectrophotometric method for estimation on albendazole and ivermectin in tablet dosage forms. Pure drug sample of albendazole and ivermectin were dissolved in a mixture of methanol and 1 N HCl (70:30). Two wavelengths selected for formation and solving the simultaneous equations were 248.8 nm for albendazole and 314.4 nm f...

Ivermectin is a gold standard antiparasitic drug that has been used successfully to treat billions of humans, livestock and pets. Until recently, the binding site on its Cys-loop receptor target had been a mystery. Recent protein crystal structures, site-directed mutagenesis data and molecular modelling now explain how ivermectin binds to these receptors and reveal why it is selective for inver...

To date, the ivermectin resistance in nematode parasites has been reported and many studies are carried out to determine the causes of this problem. A free-living Caenorhabditis elegans is used as a model system for this study to investigate the response of C. elegans to ivermectin exposure by using larval development assay. Worms were exposed to ivermectin at concentration from 1 ng/mL to 10 n...

following ivermectin treatment. Tmnsaczions of the Royal Sociey of Tropical Medicine and Hygiene, 86, 287-288. Kombila, M., Duong, T. H. & Richard-knoble, D. (1995). Safety of ivermectin for treating onchocerciasis in populadons where loiasis is Co-endemic (Central Africa: Gabon), American Journal of Tmpical Medicine and Hygiene, 53, supplement, 260-261. Mak, J. W., Navaratnam, V., Grewel, J. S...

Rosacea is a chronic dermatological disorder with a variety of clinical manifestations localized largely to the central face. The unclear etiology of rosacea fosters therapeutic difficulty; however, subtle clinical improvement with pharmacologic treatments of various drug categories suggests a multifactorial etiology of the disease. Factors that may contribute to disease pathogenesis include im...

As part of the WHO Onchocerciasis Control Programme in West Africa (OCP), the attack phase of operations in the Niger basin in Guinea began in 1989 with the simultaneous use of ivermectin and vector control. Larvicide applications coupled with annual large-scale ivermectin distribution have greatly reduced blackfly infectivity (by 78.8% for the number of infective larvae per 1000 parous flies)....

The effect of increasing concentrations of ivermectin on adenosine triphosphatase (ATPase) activity was investigated in adult worms of Onchocerca volvulus. Mean Mg- and Na,K-ATPase activities decreased significantly (F ratio = 29.82, P < 0.01 and F ratio = 28.54, P < 0.01, respectively) with increasing concentrations of ivermectin (0-100 ng/ml) in the female worms. When male and female worms we...

There have been no reports of serious adverse reactions with the use of topical ivermectin in a limited number of patients (i.e., fewer than 400).1,2 Ivermectin 0.5% lotion does not have the neurotoxicity concerns of lindane or the flammability concerns of malathion (Ovide).2,3 The safety of the lotion has not been established in patients younger than six months, and use in this age group is no...

BACKGROUND The morbidity and socioeconomic effects of onchocerciasis, a parasitic disease that is primarily endemic in sub-Saharan Africa, have motivated large morbidity and transmission control programmes. Annual community-directed ivermectin treatment has substantially reduced prevalence. Elimination requires intensified efforts, including more efficacious treatments. We compared parasitologi...