Human herpesviruses (HHVs) are able to escape from complete clearance by the immune system. Their ability to become latent is due to their delicate interferences with the immune system. This characteristic makes some of them known as important tumor viruses. Based on the prevalence of the seropositivity for the HHV-8, the world can be divided into 4 regions, one of which is the Middle East with...

How to cite this article: Charfi S, Chaabane H, Chaari I, Kallel R, Turki H, Boudawara TS. De novo anaplastic Kaposi sarcoma in a HIV-negative man: A case report and review of the literature. Our Dermatol Online. 2017;8(3):296-299. Submission: 18.09.2016; Acceptance: 24.11.2016 DOI: 10.7241/ourd.20173.85 De novo anaplastic Kaposi sarcoma in a HIV-negative man: A case report and review of the li...

A seronegative middle-aged Saudi man with history of Kaposi sarcoma, presents a recurrent dusky brown nodular lesion on the thigh. Histopathologic examination showed spindle cell intervening slit-like vascular spaces that are immunoreactive to HHV-8.

Kaposi sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA herpesvirus belonging to the gamma-herpesvirinae subfamily. KSHV has been associated with the development of three neoplastic diseases: Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). In this review, we discuss the three KSHV-associated malignancies, KSHV genome, latent and lyti...