Periostin, a secreted extracellular matrix protein, is highly expressed in wound healing and in various types of human cancer and is involved in angiogenesis. Keloids, considered dermal benign tumors, are granulomatous lesions characterized by capillary proliferation. However, the underlying regulatory mechanism of angiogenesis in keloids remains to be elucidated. The present study aimed to exa...

IntroductIon: Unstable keloids are one of the most frustrating clinical problems in wound healing and the pathogeneses remains largely unknown. To date, little is known in the literature about the microsurgical management of unstable and middle-sized keloids on the trunk, and a clear consensus is lacking. Perforator flaps are thin and pliable, have a robust blood supply, potentially release the...

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BACKGROUND The urokinase-mediated plasminogen activation (uPA) system plays a central role in a number of cellular processes including tissue remodeling, cell migration, and angiogenesis. Elevated uPA activity has also been seen with tumor invasion and metastasis in a variety of malignancies. Keloids represent an aberrant form of wound healing characterized by uncontrolled growth with invasion ...

Keloid formation is one of the most challenging clinical problems in wound healing. With increasing frequency of open heart surgery, chest keloid formations are not infrequent in the clinical practice. The numerous treatment methods including surgical excision, intralesional steroid injection, radiation therapy, laser therapy, silicone gel sheeting, and pressure therapy underscore how little is...

Aim: The aim of the study was the evaluation in vivo of the differences between the microcirculatory characteristics of the scars (keloids and hypertrophic scars) and healthy skin. Material and methods: Twenty three patients with keloids and twenty with hypertrophic scars were included in the study, evaluating fifty six scar areas and twenty healthy skin areas by means of contact optical probe ...

BACKGROUND Keloids grow and spread horizontally, like malignant tumors, for reasons that remain unknown. Yet, stretching tension is clearly associated with keloid generation, as keloids tend to occur on high tension sites such as the anterior chest and scapular region. Thus, we analyzed the relationship between keloid growth patterns and stretching tension using a visualized finite element stud...

Keloids are benign, fibroproliferative dermal tumors that typically form due to abnormal wound healing. Current standard of care is generally ineffective and does not prevent recurrence. To characterize keloid scars better understand the mechanism their formation, we performed transcriptomic profiling biopsies from a total 25 subjects diverse racial ethnic origins, 15 whom provided paired non-l...

The long non-coding RNAs (lncRNAs) regulating encoding transcripts/genes involved in Wnt signalling pathway in keloids is largely unclear. We used a pathway-focused lncRNA microarray to detect the differentiated expression profiles of both lncRNAs and genes involved in Wnt pathway, thus a total of 116 Wnt-targeted genes and 69 Wnt-related lncRNAs aberrantly expressed in keloids were initially i...

Keloids are a fibroproliferative disorder of unknown etiology developing in the skin after injury or spontaneously. The aim of this thesis is to gain deeper insight into the role of TGF-β and its signaling pathway proteins, SMADs, in the pathogenesis of keloids and describe the gene expression profile in different keloid sites in the search for potential target genes for future treatment. Furth...