PURPOSE To examine the conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca (SS-KCS) and non-Sjögren's keratoconjunctivitis sicca (NS-KCS) for evidence of immune-based inflammation. METHODS Conjunctival biopsy specimens were obtained from 15 patients with SS-KCS and 15 with NS-KCS. Immunohistochemistry was performed on frozen sections to characterize and quantify T-cell ...

OBJECTIVES The aim of this study was to report the type and frequency of ocular manifestations in Brazilian psoriatic arthritis patients. METHODS We conducted a cross-sectional study in a Brazilian tertiary hospital. The test group included 40 patients who had psoriatic arthritis according to the Classification Criteria for Psoriatic Arthritis. A control group of 40 individuals was matched fo...

Rheumatoid arthritis (RA) is a systemic inflammatory disease associated with a number of extra-articular organ manifestations. Ocular manifestations involved with RA are keratoconjunctivitis sicca, episcleritis, scleritis , corneal changes, and retinal vasculitus. The etiopathogenesis of this autoimmune disorder is still unknown. Aim of our study was to present different ocular manifestations o...

PURPOSE To evaluate the ocular presentation, treatment, and clinical course of graft-versus-host disease (GVHD). DESIGN Retrospective case series. PARTICIPANTS Two hundred and forty-nine patients with systemic GVHD were included in the study. METHODS Ocular and systemic data were collected from 2003 to 2013. MAIN OUTCOME MEASURES Mortality, visual acuity, and response of ocular symptoms...

OBJECTIVE To study the effects of lacrimal gland removal on basal and reflex tear production and on the ocular surface in the squirrel monkey. METHODS Unilateral main lacrimal gland removal in 6 squirrel monkeys was followed by Schirmer testing, slit-lamp examination with fluorescein, and collection of basal and reflex (stimulated) tears for analysis of tear protein spectra between 0 and 20 k...

PURPOSE To study the predisposing conditions, treatments, and visual outcomes of nontraumatic corneal perforations. METHODS A retrospective chart review was conducted of all nontraumatic corneal perforations seen between January 1992 and December 1998, with > or = 3 months of follow-up, at the Cornea Service Wills Eye Hospital. RESULTS A total of 40 nontraumatic corneal perforations was ana...

In 1943 Henrik Sj6gren first described the syndrome which bears his name. It is generally recognized that the diagnosis can be made when any two of the following three features are present: xerostomia with or without salivary gland enlargement, keratoconjunctivitis sicca, and connective tissue disease, usually rheumatoid arthritis (Bunim, 1961; Bloch and Bunim, 1963). The xerostomia and keratoc...

OBJECTIVE To evaluate the use and complications of a penetrating keratoprosthesis implantation in the management of corneal opacification in dogs. METHODS A retrospective clinical study describes the indications for the surgical technique utilized and the outcomes of this procedure in 20 eyes of 19 dogs with blindness of corneal origin. A successful surgical outcome was defined as a clear ker...

The recent interest in the HL-A typing as applied to the rheumatic diseases (Brewerton, Caffrey, Hart, James, Nicholls, and Sturrock, 1973; Schlosstein, Terasaki, Bluestone, and Pearson, 1973) has prompted us to investigate the possible association of an HL-A antigen in patients with the 'sicca syndrome', viz. keratoconjunctivitis sicca and xerostomia. Birch, Bunim, and Bloch (1963) in a clinic...