Increasing evidence suggests a link between attention, working memory, serotonin (5-HT), and prefrontal cortex activity. In an attempt to tease out the relationship between these elements, this study tested the effects of the hallucinogenic mixed 5-HT1A/2A receptor agonist psilocybin alone and after pretreatment with the 5-HT2A antagonist ketanserin. Eight healthy human volunteers were tested o...

Background Serotonin may contract human large coronary arteries through two 5-hydroxtryptamine (5-HT) receptors, 5-HT1-like and 5 -HT2. These 5-HT1-like receptors resemble both cloned 5-HT1D receptor subtypes, 5-HT'1D, and 5 -HT1Ds. Although these subtypes have similar pharmacology, 5-HT1Dg receptors appear to have lower affinity for ketanserin than 5-HT1Di receptors. We assessed the relative p...

this study was designed to examine the effects of intracerebroventricular (icv) injection of ketanserin(5-ht2a receptor antagonist) and sb242084 (5-ht2c receptor antagonist) on harmaline induced feeding anddrinking response in 24-h food-deprived (fd24) broiler cockerels. at first, guide cannula was surgicallyimplanted in the right lateral ventricle of chickens. in experiment 1, birds were injec...

The psychedelic lysergic acid diethylamide (LSD) has experienced a revival in research, including clinical trials that evaluate LSD-assisted psychotherapy. LSD induces perceptual alterations and influences emotion processing ways may support Here, we investigated the effects of on emotional empathy mediating role serotonin 5-hydroxytryptamine-2A (5-HT 2A ) receptor by administering 25, 50, 100,...

Dear Editor: Accumulated evidence suggests that serotonin 2A (5-HT2A) receptors are implicated in the pathology of schizophrenia. However the results remain inconclusive, particularly in the case of binding studies using postmortemtissue.We agreewith Dean's comment that our recent paper (Kang et al., 2009) reported a decrease in the density of [3H] ketanserin binding to the 5-HT2A receptors in ...

We studied the effects of serotonin on pial arterioles in anesthetized cats equipped with acutely implanted cranial window for the observation of the pial microcirculation. Serotonin topically applied caused cerebral arteriolar constriction. Ketanserin, a specific 5-HT2 inhibitor, completely blocked the vascular response of serotonin. Aggregated platelet supernatant was topically applied and ca...

BACKGROUND Serotonin may contract human large coronary arteries through two 5-hydroxytryptamine (5-HT) receptors, 5-HT1-like and 5-HT2. These 5-HT1-like receptors resemble both cloned 5-HT1D receptor subtypes, 5-HT1D alpha and 5-HT 1D beta. Although these subtypes have similar pharmacology, 5-HT1D beta receptors appear to have lower affinity for ketanserin than 5-HT1D alpha receptors. We assess...